Lung cancer is one of the most common human malignancies globally (Barnett, 2017). Based on Cancer Statistics 2012, there were 1.8 million new cases diagnosed and 1.6 million deaths claimed by this disease (Siegel et al., 2012), making lung cancer the most common cancer-related death in men while the second in women only after breast cancer. Histologically, lung cancer is mainly categorized into two types: small cell lung carcinoma (SCLC) and non-small cell lung cancer (NSCLC). Long-term tobacco smoking contributes to the huge majority of morbidity of lung cancer (Lin et al., 2008), and other recognized risk factors include combination of genetic abnormalities (Dai et al., 2019), radon gas, asbestos, and other forms

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