In this research, a kind of non-carbonized reduced graphene oxide (RGO)-cellulose nano bers (CNF) lm is constructed by a combination of ltration and chemical reduction. In the hybrid, RGO enhances conductivity of CNF, and CNF as an idea spacer not only prevents stacking of RGO but also gives the lm good mechanical properties including mechanical strength and exibility. The synergistic effect of both endows the lm with good electrochemical storage performance and outstanding mechanical properties. The hybrid lm can be directly assembled into a symmetrical supercapacitor that shows an outstanding cycle stability, excellent rate performance, good mechanical strength and exibility. Moreover, the lm presents a high speci c capacitance of 120 mF cm − 2 , energy density of 536 µWh cm − 2 (32 Wh kg − 1) and power density of 193 mW cm − 2 (53 kW kg − 1). Additionally, the lm can be used as a substrate to graft other components.
Lipid accumulation, oxidative stress, and inflammation in hepatocytes are features of nonalcoholic fatty liver disease (NAFLD). Garcinia biflavonoid 1a (GB1a) is a natural product capable of hepatic protection. In this study, the effect of GB1a on anti-inflammatory, antioxidant, and regulation of the accumulation in HepG2 cells and mouse primary hepatocytes (MPHs) was investigated, and its regulatory mechanism was further explored. The result showed that GB1a reduced triglyceride (TG) content and lipid accumulation by regulating the expression of SREBP-1c and PPARα; GB1a reduced reactive oxygen species (ROS) and improved cellular oxidative stress to protect mitochondrial morphology by regulating genes Nrf2, HO-1, NQO1, and Keap1; and GB1a reduced the damage of hepatocytes by inhibiting the expression of inflammatory cytokines interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), and nuclear factor kappa B (NF-κB) p65. The activities of GB1a were lost in liver SIRT6-specific knockout mouse primary hepatocytes (SIRT6-LKO MPHs). This indicated that activating SIRT6 was critical for GB1a to perform its activity, and GB1a acted as an agonist of SIRT6. It was speculated that GB1a may be a potential drug for NAFLD treatment.
In this research, a kind of non-carbonized reduced graphene oxide (RGO)-cellulose nanofibers (CNF) film is constructed by a combination of filtration and chemical reduction. In the hybrid, RGO enhances conductivity of CNF, and CNF as an idea spacer not only prevents stacking of RGO but also gives the film good mechanical properties including mechanical strength and flexibility. The synergistic effect of both endows the film with good electrochemical storage performance and outstanding mechanical properties. The hybrid film can be directly assembled into a symmetrical supercapacitor that shows an outstanding cycle stability, excellent rate performance, good mechanical strength and flexibility. Moreover, the film presents a high specific capacitance of 120 mF cm− 2, energy density of 536 µWh cm− 2 (32 Wh kg− 1) and power density of 193 mW cm− 2 (53 kW kg− 1). Additionally, the film can be used as a substrate to graft other components.
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