Tolerance to bacterial cell wall components is an adaptive host response. Endotoxin/LPS tolerance is characterized by a survival advantage against subsequent lethal LPS challenge. However, it is uncertain whether LPS tolerance can afford protection against other septic challenges. In this study, we show that tolerance induced by bacterial lipoprotein (BLP) protects mice against not only BLP-induced lethality, but also LPS-, live bacteria-, and polymicrobial sepsis-induced lethality. In contrast, LPS tolerance offers no survival benefit against the latter two challenges. Furthermore, induction of BLP tolerance results in overexpression of complement receptor type 3 and FcγIII/IIR on neutrophils (polymorphonuclear neutrophils) and peritoneal macrophages, with increased bacterial recognition and bactericidal activity, whereas LPS-tolerized mice exhibit an impaired ability to ingest and to kill bacteria. These results indicate that BLP tolerance is a novel adaptive host response associated with a unique protective effect during septic shock.
Incompetence of the urethral sphincter mechanism is uncommon in male dogs. This paper reviews 54 cases. As in the bitch, the condition can occur either as a congenital or as an acquired condition, in which neutering may play a part; larger breeds appear to be at greater risk. Incontinence is more likely to occur when the intra-abdominal pressure might be expected to increase, for example when the dog is recumbent. In comparison with the bitch, the condition appears less likely to respond to medical therapy and its pathophysiology is poorly understood.
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