Solvent stabilization of initial state (along x, y axis) leads to looser TS (vector z).

Second-order rate constants were measured for thiophosphinoyl group transfer from the substrates 3a-g to oxygen nucleophiles in 50% water-50% ethanol and 30% water-70% ethanol mixtures, to obtain solvent-independent Brønsted coefficients...

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088ChemInform Abstract The kinetics of the reactions of the title compound (I) with the following sec.-prim. amine (II) pairs are studied: in DMSO: piperidine-butylamine and morpholine-benzylamine, in MeCN: piperidine-butylamine. The predominant reaction in all cases is nucleophilic displacement at the aryl carbon to give the arylamines (III), accompanied by an SN2 attack at the alkyl carbon when sec. amines are the nucleophiles to give phenol (IV) (mechanism; products are determined spectrophotometrically, no yields given).

Abstract. The 2-phenylsulphonamide derivatives of amino acids were synthesis by simple substitution of benzenesulphonylchloride (6) with amino acids (1-5) containing pharmacological active functionalities. Structures of the synthesised compounds (7a-7e) were characterised using FT-IR, NMR ( 1 H, 13 C) and elemental analysis. The anti bacterial activities of the synthesised compounds were evaluated against gram positive bacteria: Staph and Streptococcus, gram negative bacteria: E-coli, Klebsiella, Proteus, and pseudomonas using 200 µl of 10 mg/ml and minimum inhibitory concentration (MIC) were also determined. The compounds exhibited effective anti bacterial properties though some are not more active than the standard drug ciprofloxacin.