Summary The tumour suppressor gene p53 has been found to be mutated or inactivated at high frequency in several common human tumours. We have examined a series of exocrine pancreatic carcinomas for overexpression of mutant forms of p53 by immunohistochemistry with a panel of specific antibodies. We found immunodetectable p53 in 13 of 22 Carcinoma of the exocrine pancreas is the fourth most common cause of death from cancer, leading to 6,000 deaths per year in the UK, and its incidence appears to be rising in Western nations (Williamson, 1988 (Kloppel & Maillet, 1989).We also studied 13 pancreatic cancer cell lines, some of which we obtained from the American Type Culture Collection (MiaPaCa-2, BxPC-3, CaPan-1, CaPan-2, AsPC-1, PSN-

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Aim: The purpose of this study was to illuminate the experiences of older adults' return to leisure activities, following rehabilitation, post-stroke. Method: A phenomenological approach was used to explore the experiences of re-engaging in leisure occupations post-stroke. In-depth interviews were conducted with five community-dwelling individuals (three men, two women) aged 68-74 years who had experienced a stroke in the past year. Data were analysed using thematic analysis. Findings: Four themes emerged: (i) Re-engaging in leisure activities, (ii) acceptance of physical limitations poststroke, (iii) gratitude for help and support and (iv) looking forward to the future. Conclusion: Implications revealed that post-stroke interventions need a more occupation-focussed approach, including return to leisure at an earlier stage of stroke rehabilitation.