Pulmonary blastomas are rare lung neoplasms constituting 0.5% of all lung tumors. This tumor has an aggressive course and needs to be recognized on cytology. A preoperative diagnosis of pulmonary blastoma is difficult to obtain by cytopathologic methods. A diagnosis of biphasic pulmonary blastoma should be considered when there is a dimorphic population of cells on cytology. A 30-year-old male presented with gradually progressing breathlessness and left-sided chest pain for the past one month. Chest radiograph and computed tomography of thorax revealed an anterior mediastinal mass that was subjected to ultrasound-guided fine-needle aspiration cytology. Aspiration cytology showed a highly cellular lesion with a dimorphic population of tumor cells in a necrotic background. The possibility of a non-small cell carcinoma was suggested. Subsequent histopathology revealed the tumor to be a pulmonary blastoma. The importance of recognizing the dimorphic population of cells in cytology is discussed.
Objective: Pulmonary hypoplasia is common in the perinatal period and causes death in newborn infants. It is commonly associated with a number of malformation syndromes. Various parameters are used to estimate pulmonary hypoplasia at fetal autopsy including Lung Weight Body Weight ratio (LW:BW), Radial Alveolar Count (RAC) and DNA estimation. Material and Method: This study was carried out as a retrospective analysis of 108 lung specimens of fetuses with congenital anomalies for a period of five years. All terminated fetuses with anomalies were received with 10% formalin. An inverted Y-shaped incision was made on the fetus to remove the lungs. Lung weight and body weight were measured and the ratio was calculated. Morphometric estimation of RAC was done microscopically by counting the number of alveoli using the Q capture software. RAC was calculated based on gestational age. Results: Among the restrictive lung diseases, pulmonary hypoplasia by the LW:BW ratio was prevalent in 43% while the same by RAC was 19%. Similarly, pulmonary hypoplasia by the LW:BW ratio was prevalent in 35% while the same by RAC was 26% among cases with non restrictive lung diseases. Oligohydramnios showed the highest prevalence of pulmonary hypoplasia (23.7%), followed by renal anomalies (16.9%) and CNS anomalies (15.2%). Conclusion: Pulmonary hypoplasia is a common occurrence in many congenital anomalies, premature rupture of membranes, and hydrops fetalis. Identifying the anomaly during the intrauterine period will help to anticipate and accordingly manage the baby in the postpartum period. Early diagnosis of correctable condition like oligohydramnios will also help in the early intervention and prevention of pulmonary hypoplasia.
To study the spectrum and have a clinicopathological correlation of papulosquamous skin lesions. Material and Methods: A series of noninfectious papulosquamous skin lesions coming to Department of Dermatology were studied over a period of one year, i.e. from June 2017 to July 2018. These were correlated and analysed with the histopathological findings. Results: The present study comprised of 70 cases of skin diseases presenting as papulosquamous lesions. Majority of cases were in the age group of 31 to 40 years (16 cases, 22.8%) followed by 11 to 20 years (15 cases, 21.4%). Females were more commonly affected with 37 cases(52.8%) compared to males with 33cases (47.1%) and female to male ratio of incidence being 1:0.89. In the present study, out of 70 cases, 34 cases (48.5%) were diagnosed as psoriasis, Lichen planus-15 cases(21.4%), Chronic Dermatitis-4 cases (5.71%), Lichen striatus-3 cases (4.28%), Pityriasis Lichenoides-2 cases(2.85%), Pityriasis Rosea-2 cases (2.85%), Prurigo Simplex-2 cases(2.8%), Prurigo Nodularis and Lichen Nitidus 1 case each, 1 case each of atopic eczema, contact dermatitis and chronic actinic dermatitis and inconclusive cases being 3. The histopathological findings of psoriasis and lichen planus were studied with special emphasis. The predominant histopathological finding in psoriasis is acanthosis and the predominant histopathological finding in lichen planus was band like infiltrate in the dermoepidermal junction. These findings in addition to other specific findings and clinical correlation were used to give a conclusive diagnosis. There were 4 cases of psoriasis, 2 cases of lichen planus, 2 cases of 1 case of, 1 case of which did not correlate with histopathological findings. Conclusions: In our study females were mostly affected. The age group mainly affected was 31-40 years. Psoriasis was the commonest papulosquamous lesion. Good clinicopathological correlation is very much necessary for diagnosis.
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