Hypervalent tellurium
compounds (telluranes) are promising therapeutical agents with negligible
toxicities for some diseases in animal models. The C–Te bond
of organotellurium compounds is commonly considered unstable, disfavoring
their applicability in biological studies. In this study, the stability
of a set of telluranes composed of an inorganic derivative and noncharged
and charged organic derivatives was monitored in aqueous media with
1
H,
13
C, and
125
Te NMR spectroscopy and
high-resolution mass spectrometry. Organic telluranes were found to
be remarkably resistant and stable to hydrolysis, whereas the inorganic
tellurane
AS101
is totally converted to the hydrolysis
product, trichlorooxytellurate, [
TeOCl
3
]
−
, which was also observed in the hydrolysis
of
TeCl
4
. The noteworthy stability
of organotelluranes in aqueous media makes them prone to further structure–activity
relationship studies and to be considered for broad biological investigations.
Internal bis-substituted propargylic diols were subjected to enzymatic kinetic resolution promoted by CAL-B. Employing a two round sequence EKR, mono- and bis-acetoxy propargylic products were obtained in a high enantiomeric ratio (E > 200). The efficiently resolved chiral 8b was applied in a concise synthesis of (S)-1b, an optically active natural product produced by fungi Clitocybe catinus.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.