Hyaluronic acid (HA) intraarticular injection is used in the management of osteoarthritis in veterinary medicine. However, HA oral administration is less common given the scarce currently available scientific evidence. This study was aimed at evaluating the effects of oral HA administration on synovial fluid concentrations of several selected biomarkers in dogs with cranial cruciate ligament (CCL) injury operated on using the tibial tuberosity advancement (TTA) technique. Fifty-five dogs were included in this prospective, randomized, double-blind, clinical study; they were randomly assigned to receive either a placebo (group A; n = 25) or HA (group B; n = 30) orally for 10 weeks. Synovial fluid samples were obtained before surgery, and at 10 weeks postoperatively to measure concentrations of HA, haptoglobin, nitric oxide, and paraoxonase-1. After 10 weeks, group HA showed a significant increase in HA concentration (p = 0.0016) and a significant decrease in PON-1 concentration (p = 0.011) compared to baseline. In conclusion, post-op oral HA administration in canine patients with CCL injury leads to improvements in osteoarthritis biomarkers, namely higher synovial fluid HA concentrations and reduced synovial fluid paraoxonase-1 concentrations. These findings support the bioavailability of orally-administered HA and its usefulness in improving biomarkers of osteoarthritis.
The aim of the study is to report the results obtained from performing a Proximal Abduction Ulnar Osteotomy (PAUL) technique in a cohort of dogs with medial compartment disease with short- and long-term follow-up, assessing the perception of the owners and describing the long-term complications associated with the technique. This is a clinical prospective study, including dogs diagnosed with medial compartment disease treated with elbow arthroscopy and PAUL between 2013 and 2020. Long-term followup data and postoperative complications were registered, and a questionnaire adapted from Fitzpatrick et al. 2009 was collected from owners. Thirty-three elbows in 26 dogs were included. The duration of followup ranged from 4 to 61 months (median: 24.76 months). At the end of the study, 73.1% of the owners reported excellent satisfaction and 74.1% of the owners would repeat the surgery in the same circumstances. The owner questionnaire showed a greater capacity to walk and run, without lameness and pain, and climb up and down stairs a year after surgery, being constant at the end of the study. Major postoperative complications were documented in 4/33 elbows (12.12%), including delayed union, implant failure, and osteophytosis of the medial aspect of the coronoid process. In conclusion, elbow arthroscopy and the PAUL technique achieved an evident improvement in the quality of life of patients with great satisfaction for most of the owners.
Angular deformity is a common condition in dogs that can cause serious malformations and is a challenge for surgeons to correct. A 15-monthold male Saint Bernard was evaluated due toright foreleg lameness. Orthopedic examination revealed a valgus deformity with external rotation and anteversion of the forelimb. Carpal examination revealedthe decreased range of motion with slight disturbances in carpal flexion. Radiography of both forelimbs showed angular deviation because of possible premature physeal closure of the distal ulnar growth plate.Surgical intervention was selected to correct the angular deformity. A closed-wedge osteotomy was planned using 3D reconstruction, obtained via computed tomography (CT). In order to accomplish this, a custom-made device was developed to aid the surgeon in establishing the position and orientation of the cutting planes during the intervention.Long-term follow-up obtained 3 years after surgery revealed the correct ossification of the osteotomy and complete resolution of lameness. The main advantages of using a customized device obtained from 3D CT include the predictability and accuracy of the method. The device allows for correction of atriple-axis angular long bone deviation, with full opposition between the bone fragments after osteotomy and minor loss of length of the limb.
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