Hypertension is one of the major risk factors associated with cardiovascular diseases, requiring the discovery of new pharmacologically active compounds. The versatility of Morita-Baylis-Hillman (AMBH) adducts from the perspective of medicinal chemistry has been placing this class of polyfunctional molecules in evidence in recent years due their expressive biological activities. Therefore, this work describes an exploratory study of the potential vasorrelaxant activity of AMBH derived from eugenol. These compounds were tested by cumulative addition (10 -10 to 3x10 -4 Molar) in superior mesenteric arteries isolated from normotensive rats pre-contracted with phenylephrine (10 μM). In the presence of functional endothelium, the MBHAs promoted significant vasorelaxation but lower than when compared to the MBHAs derived from eugenol (3a = 103.3 ± 2.6 %, 3b = 105.0 ± 2.5 % and 3c = 69.2 ± 7.1 %) and eugenol 2 (101.8 ± 3.0). The vasorelaxant effect in the absence of the functional endothelium of the most promising compounds (3a and 3b) showed that both compounds promoted vasorelaxation by acting directly on the vascular smooth muscle layer.
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