Objective To test whether tissue oxygen saturation (StO 2 ) after a venous occlusion test estimates central venous oxygen saturation (ScvO 2 ). Methods Observational study in intensive care unit patients. Tissue oxygen saturation was monitored (InSpectra Tissue Spectrometer Model 650, Hutchinson Technology Inc., MN, USA) with a multiprobe (15/25mm) in the thenar position. A venous occlusion test in volunteers was applied in the upper arm to test the tolerability and pattern of StO 2 changes during the venous occlusion test. A sphygmomanometer cuff was inflated to a pressure 30mmHg above diastolic pressure until StO 2 reached a plateau and deflated to 0mmHg. Tissue oxygen saturation parameters were divided into resting StO 2 (r-StO 2 ) and minimal StO 2 (m-StO 2 ) at the end of the venous occlusion test. In patients, the cuff was inflated to a pressure 30mmHg above diastolic pressure for 5 min (volunteers’ time derived) or until a StO 2 plateau was reached. Tissue oxygen saturation parameters were divided into r-StO 2 , m-StO 2 , and the mean time that StO 2 reached ScvO 2 . The StO 2 value at the mean time was compared to ScvO 2 . Results All 9 volunteers tolerated the venous occlusion test. The time for tolerability or the StO 2 plateau was 7 ± 1 minutes. We studied 22 patients. The mean time for StO 2 equalized ScvO 2 was 100 sec and 95 sec (15/25mm probes). The StO 2 value at 100 sec ([100-StO 2 ] 15mm: 74 ± 7%; 25mm: 74 ± 6%) was then compared with ScvO 2 (75 ± 6%). The StO 2 value at 100 sec correlated with ScvO 2 (15 mm: R 2 = 0.63, 25mm: R 2 = 0.67, p < 0.01) without discrepancy (Bland Altman). Conclusion Central venous oxygen saturation can be estimated from StO 2 during a venous occlusion test.
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