Bile acids play an important role in modulating cancer therapy and novel derivatives with cytotoxic activity not restricted to the gastrointestinal tract can be expected. Selective toxicity targeting the bacterial membrane remains an attractive area of research for further development of bile acid-based bactericidal agents. On the other hand, the neuroprotective properties of some bile acids offer therapeutic potential in neurodegenerative disorders. Bile acid-based nanoparticles are also a growing research area due to the unique characteristics and tunable properties of these nanosystems. Therefore, multifaceted pharmaceutical and biomedical applications of bile salts are to be expected in the near future.
The
mixed micelle formation in basic aqueous solutions between
an anionic gemini amino acid-based surfactant derived from cysteine
(C8Cys)2 and the bile salts sodium cholate (NaC)
and sodium deoxycholate (NaDC) has been studied by conductivity, and
the results have been compared with the ones obtained for binary solutions
of (C8Cys)2 with the conventional anionic surfactant
sodium dodecyl sulfate (SDS). A nonideal mixing pattern was observed
for the mixed systems, and a striking behavior was found for the gemini
surfactant–bile salt mixtures, with gemini–bile salt
interactions changing from synergistic to antagonistic with increasing
gemini surfactant composition, whereas for the (C8Cys)2/SDS mixed system, synergism was attained over all the molar
fraction range studied. Regular solution theory (RST) was used to
analyze the gemini surfactant–anionic surfactant binary mixtures,
and the interaction parameter (β) has been evaluated, as well
as mixed micelle composition.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.