Tight junctions (TJs) are cell-cell junctions that seal the intercellular space between neighboring cells. They consist of a variety of TJ transmembrane proteins, eg, claudins (Cldns), occludin (Occl), and junctional adhesion molecules (JAMs) as well as of TJ-plaque proteins, eg, ZO-1 to -3, symplekin, and cingulin (reviewed in Refs.
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