Combination of a new and highly efficient robotic system for
high-throughput reaction screening with a thin-layer chromatography (TLC) scanner is described. The system consists of a
parallel synthesis robot capable of performing up to several
hundred reactions in parallel and a second robot for analytical
sample workup, dilution, and TLC-spotting. The automatically
prepared TLC plates are analyzed with a modern TLC scanner
which gives rapidly semi-quantitative analytical results on the
outcome of the single reactions. Several automated chemistry
examples clearly demonstrate the high efficiency of this combined system and its superiority compared to more classical
approaches, e.g., HPLC analyses.
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