With the goal of contributing to the growth of research on people with disabilities in employment, in particular in relation to their job satisfaction (JS), organizational commitment (OC), and turnover intention (TI), this study explores the effect of JS on TI among employees with disabilities and the moderation effect of OC and its four dimensions on this main relationship. A total of 245 Special Employment Center (SEC) employees in Spain answered a questionnaire. To analyze the results, a descriptive analysis with bivariate correlations across the variables was performed, and the moderation model was tested subsequently using macro PROCESS for SPSS by Hayes. For the significant effects, a pick-a-point approximation was used to interpret the results. The results show that OC and its dimensions have no significant effect on the direct relationship. However, some components of JS, such as the relationship with coworkers and with supervisors, play a significant role in the relationship with TI when moderated by affective and value commitment. Our results show that it is important that human resources departments create conditions favoring a work environment with positive interpersonal relationships between employees and managers in order to minimize TI at SECs.
We have studied the IL-5 production and responsiveness in the mouse brain. Both IL-5 and IL-5 receptor alpha chain (IL-5 Ralpha) were expressed in vitro in astrocytes, but not in neurons. IL-5 was expressed at constant levels during brain development, after birth, and in the adult brain of both normal mice and mice bearing infection or allergic reaction associated with high Th2 lymphocyte reactivity. Conversely, expression of IL-5 Ralpha was highly regulated both in quantitative terms and in the number of alternatively spliced isoforms. In embryos, we observed the classical transmembrane isoform and two new larger ones, in addition to three smaller soluble isoforms. At birth, a single soluble isoform was generated, and in the post-natal period, the major transmembrane and two or three soluble isoforms were detected. In adulthood, no expression of IL-5 Ralpha was detected in normal mice, but all the isoforms were produced in mice with inflammatory reactions. We propose that IL-5 has a specific autocrine and/or paracrine function in astrocytes, maintaining the homogeneity of the activation state in a given astrocyte population. The alternative splicing of IL-5 Ra modulates the brain tissue from the fully unresponsive to the highly sensitive state in regard to IL-5 stimulation. According to our results, IL-5 Ralpha splicing is controlled by an intrinsic program in the brain during the embryonic and postnatal periods, and an extrinsic systemic program reflecting the inflammatory reactions associated with high systemic IL-5 levels.
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