The SSB generation process is homogeneous and independent of the LET of the particles involved, at least within the proton and alpha particle energy range here studied. The target-hit probability is only determined by the ratio between the total volume occupied by targets and that of the ROI where the radiation deposits its energy. The maximum separation distance between two adjacent SSBs to produce a DSB is the parameter that breaks the homogeneity of the target-hit process, making the DSB production process strongly heterogeneous.

Attending to clients' psychological needs during career counseling merits more attention in career theory and practice. We describe how the elaboration of clients' needs during career construction counseling supports clients' problem formulation. After reviewing the literature on the psychology of needs, we present and illustrate an intervention strategy with a case example. Counseling vignettes from the initial counseling task of problem formulation illustrate how to facilitate clients' narrative symbolization of their emotional experiences and associated needs. We explain how this strategy contributes to deepening clients' understanding of their problems and facilitates both the rewriting of a career narrative and the construction of new career plans. Analysis of the possibilities and limits of this practice merits attention in career counseling process research.

Genome-scale metabolic models (GEMs) are essential tools for in silico phenotype prediction and strain optimisation. The most straightforward GEMs reconstruction approach uses published models as templates to generate the initial draft, requiring further curation. Such an approach is used by BiGG Integration Tool (BIT), available for merlin users. This tool uses models from BiGG Models database as templates for the draft models. Moreover, BIT allows the selection between different template combinations. The main objective of this study is to assess the draft models generated using this tool and compare them BIT, comparing these to CarveMe models, both of which use the BiGG database, and curated models. For this, three organisms were selected, namely Streptococcus thermophilus, Xylella fastidiosa and Mycobacterium tuberculosis. The models’ variability was assessed using reactions and genes’ metabolic functions. This study concluded that models generated with BIT for each organism were differentiated, despite sharing a significant portion of metabolic functions. Furthermore, the template seems to influence the content of the models, though to a lower extent. When comparing each draft with curated models, BIT had better performances than CarveMe in all metrics. Hence, BIT can be considered a fast and reliable alternative for draft reconstruction for bacteria models.

A obra de Remedios Varo, em especial a pintura Bordando el manto terrestre (1961), se apresenta como um caminho produtivo para aprofundar a reflexão que apresento neste artigo. A ideia é a seguinte: ao admitir, tal como propôs o teórico brasileiro Luiz Costa Lima, a presença de um controle do imaginário no Ocidente, especialmente na América Latina, e na busca por pensá-lo a partir da literatura e das relações culturais no âmbito latino-americano, encontramos certos topos que se mostram como desvios e resistências a este controle. Penso nas obras de certas mulheres estrangeiras que desenvolveram seus trabalhos no México e que de algum modo dialogam com o surrealismo, como Leonora Carrington, Kati Horna e Remedios Varo, autora da pintura que abordaremos neste trabalho.