Climate variability, land use and land cover changes (LULCC) have a considerable impact on runoff–erosion processes. This study analyzed the relationships between climate variability and spatiotemporal LULCC on runoff–erosion processes in different scenarios of land use and land cover (LULC) for the Almas River basin, located in the Cerrado biome in Brazil. Landsat images from 1991, 2006, and 2017 were used to analyze changes and the LULC scenarios. Two simulations based on the Soil and Water Assessment Tool (SWAT) were compared: (1) default application using the standard model database (SWATd), and (2) application using remote sensing multiple gridded datasets (albedo and leaf area index) downloaded using the Google Earth Engine (SWATrs). In addition, the SWAT model was applied to analyze the impacts of streamflow and erosion in two hypothetical scenarios of LULC. The first scenario was the optimistic scenario (OS), which represents the sustainable use and preservation of natural vegetation, emphasizing the recovery of permanent preservation areas close to watercourses, hilltops, and mountains, based on the Brazilian forest code. The second scenario was the pessimistic scenario (PS), which presents increased deforestation and expansion of farming activities. The results of the LULC changes show that between 1991 and 2017, the area occupied by agriculture and livestock increased by 75.38%. These results confirmed an increase in the sugarcane plantation and the number of cattle in the basin. The SWAT results showed that the difference between the simulated streamflow for the PS was 26.42%, compared with the OS. The sediment yield average estimation in the PS was 0.035 ton/ha/year, whereas in the OS, it was 0.025 ton/ha/year (i.e., a decrease of 21.88%). The results demonstrated that the basin has a greater predisposition for increased streamflow and sediment yield due to the LULC changes. In addition, measures to contain the increase in agriculture should be analyzed by regional managers to reduce soil erosion in this biome.