EDITORIAL SYNOPSIS The pattern of gastric secretion has been studied in a series of patients following the augmented histamine test and the insulin test. In the same patient, the amount of acid and pepsin secreted is remarkably similar following these two tests. In both, acid and pepsin secretion is inhibited to a similar degree by small doses of hexamethonium and atropine. It is concluded that the action of histamine in causing gastric secretion in man is not a specific one on the acidsecreting cells, nor does it act directly upon these cells. It is suggested that histamine acts through nerves.
Summary
Rats fed on a supplement of raw cabbage, brinjal, dhal or powdered milk given in addition to a staple rice or laboratory stock diet show a high degree of protection against experimental ulceration following pyloric ligation. Wheat bran and ragi (a millet) conferred some protection, whereas rice bran and maize conferred no protection. The protection conferred by raw cabbage was destroyed by cooking. The lettuce used conferred no protection. The significance of such findings with regard to the geographical distribution of duodenal ulcer in India and Africa is discussed.
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