Purpose: Fetuin-A is a hepatokine that is linked to lipid metabolism, obesity, insulin resistance, type 2 diabetes and cardiovascular disease. Elevated thyroid-stimulating hormone (TSH) levels are associated with metabolic and cardiovascular disturbances. Our aim was to determine if TSH can regulate fetuin-A levels.Methods: Fetuin-A serum levels were examined in 26 subjects (19 women; previous thyroidectomy and radioactive iodine ablation) undergoing recombinant human TSH (rhTSH) stimulation to screen for thyroid cancer recurrence. eir age was 49±10 years, and body mass index (BMI) was 28±6 (both expressed as mean±SD). e patients received two doses of rhTSH (0.9 mg), administered 24 hours apart on days 1 and 2, without discontinuation of ongoing L-thyroxine therapy. Morning blood samples were obtained on days 1 (prior to the rst dose of rhTSH), 3 and 5.Results: e baseline value of fetuin-A (mean±SD) for all participants was 527±186 mg/ L. Values of fetuin-A did not change in response to rhTSH administration. e lack of response was not dependent on gender, age, baseline free thyroxine level or BMI.Conclusion: Fetuin-A has been implicated in metabolic and in ammatory conditions, but there have been no reports on whether fetuin-A is in uenced by TSH. Within the context of rhTSH administration for surveillance of thyroid cancer recurrence, there was no e ect on serum levels of fetuin-A.
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