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Este trabalho descreve a busca de novos agentes com potencial quimioterápico baseados em complexos de metais de transição com ligantes planares. Neste estudo, complexos polipiridilpaládio foram sintetizados e caracterizados por análise elementar e por espectroscopias de RMN e de absorção no UV-visível e no infravermelho. A interação dos complexos com DNA também foi investigada por métodos espectroscópicos. Todas as bandas de transferência de carga do metal para os ligantes (TCML) dos complexos polipiridilpaládio exibiram hipocromismo e deslocamento para o vermelho na presença de DNA.

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Antimalarial drugs such as chloroquine are beneficial agents in systemic lupus and rheumatoid arthritis. In this work, two new chloroquine diphosphate (CQDP) complexes containing Zn(II) and Au(III) of formula Zn(CQDP)(NO 3 ) 2 (1) and Au(CQDP)Cl 3 (2), respectively, were synthesized and characterized by physico-chemical and spectroscopic methods. To examine their possible antiinflammatory properties, the new derivatives were tested in the range from 1 to 100 lM on the respiratory burst of isolated human neutrophils (PMNs) as well as in whole blood. In isolated PMNs, complex 1 inhibited the isoluminol-enhanced chemiluminescence (IL-CL) only at the highest concentration tested, whereas in the whole blood assay, 10 lM of this complex was sufficient to significantly inhibit the luminolenhanced chemiluminescence (L-CL). On the contrary, complex 2 dose-dependently inhibited the IL-CL but affected the L-CL only at 100 lM. In conclusion, both complexes are more active than CQDP and may be useful for future treatment of diseases resulting from exacerbated neutrophil functions.