In the presence of siloxanes as stoichiometric reductants, chiral copper-bisphosphine complexes catalyze highly enantioselective reductive Michael cyclizations of substrates containing two alpha,beta-unsaturated carbonyl moieties. The diastereochemical outcome of these reactions is dependent upon whether biaryl- or ferrocene-based chiral bisphosphines are employed.
Amino acids U 0400Negishi Cross-Coupling Reactions of α-Amino Acid-Derived Organozinc Reagents and Aromatic Bromides. -The reaction proceeds at 50°C with various palladium sources. The difference in reactivity between aromatic iodides and aromatic bromides is used to synthesize orthogonally protected, unsymmetrical phenylene bis-alanine derivative (IX). -(OSWALD, C. L.; CARRILLO-MARQUEZ, T.; CAGGIANO, L.; JACKSON*, R. F. W.; Tetrahedron 64 (2008) 4, 681-687; Dep. Chem., Univ. Sheffield, Sheffield S3 7HF, UK; Eng.) -Bartels 24-175
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