Background: Infantile hemangiomas (IHs) are thought to originate from hemangioma stem cells (HemSC), though IH pathogenesis is poorly understood. Our recent work showed that NOTCH3 is highly expressed in HemSCs and may play a role in IH progression. In cultured HemSCs, NOTCH3 knockdown perturbed adipogenesis and enhanced endothelial cell differentiation. Using a murine model of IH, we compared the development of IHs from control HemSCs (HemSC-scr) to HemSCs with Notch3 shRNA (HemSC-shN3).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.