Cerebrospinal fluid has shown itself to be an essential brain component during development. This is particularly evident at the earliest stages of development where a lot of research, performed mainly in chick embryos, supports the evidence that cerebrospinal fluid is involved in different mechanisms controlling brain growth and morphogenesis, by exerting a trophic effect on neuroepithelial precursor cells (NPC) involved in controlling the behaviour of these cells. Despite it being known that cerebrospinal fluid in mammals is directly involved in corticogenesis at fetal stages, the influence of cerebrospinal fluid on the activity of NPC at the earliest stages of brain development has not been demonstrated. Here, using "in vitro" organotypic cultures of rat embryo brain neuroepithelium in order to expose NPC to or deprive them of cerebrospinal fluid, we show that the neuroepithelium needs the trophic influence of cerebrospinal fluid to undergo normal rates of cell survival, replication and neurogenesis, suggesting that NPC are not self-sufficient to induce their normal activity. This data shows that cerebrospinal fluid is an essential component in chick and rat early brain development, suggesting that its influence could be constant in higher vertebrates.
Introducción: las enfermedades cardiometabólicas representan un importante problema de salud pública a nivel mundial. La evaluación del riesgo permitiría una intervención médica y nutricional oportuna. Objetivo: determinar la prevalencia de riesgo cardiometabólico (RCM) mediante marcadores antropométricos y la asociación entre dichos marcadores, en adultos de Teotitlán de Flores Magón, Oaxaca; México. Material y métodos: se realizó un estudio transversal, descriptivo en 208 individuos mayores de 20 años. El RCM se evaluó utilizando el índice de masa corporal, circunferencia de cintura, índice cintura–talla e índice de conicidad. Las variables se analizaron mediante estadística descriptiva; las pruebas de Chi-cuadrado de Pearson y de correlación de Spearman se utilizaron para las asociaciones y correlaciones respectivamente, considerando un nivel de significancia estadística de P < 0.05. Resultados: la prevalencia de obesidad fue mayor en mujeres (42.34%) que en hombres (35.21%). La prevalencia de RCM varió de 17.31% a 87.5%, según el marcador utilizado, encontrando correlaciones positivas significativas entre todos ellos. Las mujeres presentaron mayor prevalencia de RCM en todos los marcadores evaluados. Conclusión: los hallazgos sugieren que la antropometría es una alternativa económica viable para detectar RCM en comunidades cuyos recursos en salud son limitados, sin embargo, podría complementarse con otro tipo de marcadores.
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