The human microbiome has emerged as a central research topic in human biology and biomedicine. Current microbiome studies generate high-throughput omics data across different body sites, populations, and life stages. Many of the challenges in microbiome research are similar to other high-throughput studies, the quantitative analyses need to address the heterogeneity of data, specific statistical properties, and the remarkable variation in microbiome composition across individuals and body sites. This has led to a broad spectrum of statistical and machine learning challenges that range from study design, data processing, and standardization to analysis, modeling, cross-study comparison, prediction, data science ecosystems, and reproducible reporting. Nevertheless, although many statistics and machine learning approaches and tools have been developed, new techniques are needed to deal with emerging applications and the vast heterogeneity of microbiome data. We review and discuss emerging applications of statistical and machine learning techniques in human microbiome studies and introduce the COST Action CA18131 “ML4Microbiome” that brings together microbiome researchers and machine learning experts to address current challenges such as standardization of analysis pipelines for reproducibility of data analysis results, benchmarking, improvement, or development of existing and new tools and ontologies.

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Due to the exponential growth of the Internet of Things networks and the massive amount of time series data collected from these networks, it is essential to apply efficient methods for Big Data analysis in order to extract meaningful information and statistics. Anomaly detection is an important part of time series analysis, improving the quality of further analysis, such as prediction and forecasting. Thus, detecting sudden change points with normal behavior and using them to discriminate between abnormal behavior, i.e., outliers, is a crucial step used to minimize the false positive rate and to build accurate machine learning models for prediction and forecasting. In this paper, we propose a rule-based decision system that enhances anomaly detection in multivariate time series using change point detection. Our architecture uses a pipeline that automatically manages to detect real anomalies and remove the false positives introduced by change points. We employ both traditional and deep learning unsupervised algorithms, in total, five anomaly detection and five change point detection algorithms. Additionally, we propose a new confidence metric based on the support for a time series point to be an anomaly and the support for the same point to be a change point. In our experiments, we use a large real-world dataset containing multivariate time series about water consumption collected from smart meters. As an evaluation metric, we use Mean Absolute Error (MAE). The low MAE values show that the algorithms accurately determine anomalies and change points. The experimental results strengthen our assumption that anomaly detection can be improved by determining and removing change points as well as validates the correctness of our proposed rules in real-world scenarios. Furthermore, the proposed rule-based decision support systems enable users to make informed decisions regarding the status of the water distribution network and perform effectively predictive and proactive maintenance.

Misinformation is considered a threat to our democratic values and principles. The spread of such content on social media polarizes society and undermines public discourse by distorting public perceptions and generating social unrest while lacking the rigor of traditional journalism. Transformers and transfer learning proved to be state-of-the-art methods for multiple well-known natural language processing tasks. In this paper, we propose MisRoBÆRTa, a novel transformer-based deep neural ensemble architecture for misinformation detection. MisRoBÆRTa takes advantage of two state-of-the art transformers, i.e., BART and RoBERTa, to improve the performance of discriminating between real news and different types of fake news. We also benchmarked and evaluated the performances of multiple transformers on the task of misinformation detection. For training and testing, we used a large real-world news articles dataset (i.e., 100,000 records) labeled with 10 classes, thus addressing two shortcomings in the current research: (1) increasing the size of the dataset from small to large, and (2) moving the focus of fake news detection from binary classification to multi-class classification. For this dataset, we manually verified the content of the news articles to ensure that they were correctly labeled. The experimental results show that the accuracy of transformers on the misinformation detection problem was significantly influenced by the method employed to learn the context, dataset size, and vocabulary dimension. We observe empirically that the best accuracy performance among the classification models that use only one transformer is obtained by BART, while DistilRoBERTa obtains the best accuracy in the least amount of time required for fine-tuning and training. However, the proposed MisRoBÆRTa outperforms the other transformer models in the task of misinformation detection. To arrive at this conclusion, we performed ample ablation and sensitivity testing with MisRoBÆRTa on two datasets.