The aim of this study was to determine the anxiety and depression levels of inpatients. A cross-sectional study was conducted in Kırşehir in the middle part of Turkey with a sample of 433 inpatients. As the data-gathering tools, a questionnaire form and Hospital Anxiety and Depression Scale (HADS) were used. Statistical analyses were performed using Kruskal-Wallis Variance analysis and Mann-Whitney U-test. The mean HADS-depression scores of patients were compared according to the clinics they were in, and the difference was found to be significant for HADS-depression (P < 0.01) scores. The mean HADS-anxiety score of participants was 9.07, and the mean HADS-depression scores was 8.88. Among the participants in this study, 44.3% had an anxiety disorder (HADS-anxiety score of ≥ 10) whereas the 73.7% showed depression (HADS-depression score of ≥ 7). Results indicate that support, counselling, and routine screening for anxiety and depression should be provided to inpatients.