The nanohybrids which based on β‐cyclodextrin, platinum nanoparticles and graphene (β‐CD‐PtNPs/GNs) were successfully synthesized and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FT‐IR) and electrochemical impedance spectroscopy (EIS). Then they were used to construct a simple and reliable chiral sensing platform to interact with tryptophan (Trp) enantiomers. Differential pulse voltammetry (DPV) was used to investigate the stereo selectivity of β‐CD‐PtNPs/GNs to Trp enantiomers. After interaction, the obvious difference of peak currents of L‐Trp and D‐Trp was obtained, indicating this strategy could be employed to chiral recognition of Trp enantiomers. Under the optimum conditions, the chiral sensor exhibited a good linear response to Trp enantiomers in a linear range of 5.0×10−5 to 5.0×10−3 M with a low limit of detection of 1.7×10−5 M (S/N=3). This approach provided a new available platform to recognize and determine Trp enantiomers.
A chiral stereoselective electrochemiluminescence (ECL) sensor was constructed by using Ru–AuNPs and β-CD–rGO composites to discriminate proline enantiomers.
The nanocomposite (Au@BSA) which was synthesized using gold nanoparticles (AuNPs) and bovine serum albumin (BSA) was used as an electrochemical sensing layer for chiral recognition of propranolol (PRO).
An electrochemical sensor was explored for recognizing 3,4-dihydroxyphenylalanine (DOPA) enantiomers based on L-cysteine covalently binding with the multi-walled carbon nanotubes functionalized with 3,4,9,10-perylene tetracarboxylic acid (MWCNTs-PTCA-Cys). Here two different ways of square wave voltammetry (SWV) and cyclic voltammetry (CV) were utilized to investigate the stereospecific interaction between the MWCNTs-PTCA-Cys nanocomposite and DOPA enantiomers. The D-DOPA and L-DOPA exhibited different response in both CV and SWV, in addition, the difference in SWV was more obvious and reached to 264.9 μA, suggesting that the enantiomers could be successfully distinguished by MWCNTs-PTCA-Cys nanocomposite, and the selection of electrochemical technique played an important role in enantioselective recognition. Under the optimum conditions, the detection limits of D-DOPA and L-DOPA were 2.5 μM and 4.6 μM (S/N = 3), respectively, with a linear range of 1.0 × 10−5 M to 5.0 × 10−3 M. This work provided a simple method to recognize and determine DOPA enantiomers with rapid response, excellent recognition ability, high sensitivity and good stability.
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