In recent years, mobile devices are equipped with increasingly advanced sensing and computing capabilities. Coupled with advancements in Deep Learning (DL), this opens up countless possibilities for meaningful applications, e.g., for medical purposes and in vehicular networks. Traditional cloudbased Machine Learning (ML) approaches require the data to be centralized in a cloud server or data center. However, this results in critical issues related to unacceptable latency and communication inefficiency. To this end, Mobile Edge Computing (MEC) has been proposed to bring intelligence closer to the edge, where data is produced. However, conventional enabling technologies for ML at mobile edge networks still require personal data to be shared with external parties, e.g., edge servers. Recently, in light of increasingly stringent data privacy legislations and growing privacy concerns, the concept of Federated Learning (FL) has been introduced. In FL, end devices use their local data to train an ML model required by the server. The end devices then send the model updates rather than raw data to the server for aggregation. FL can serve as an enabling technology in mobile edge networks since it enables the collaborative training of an ML model and also enables DL for mobile edge network optimization. However, in a large-scale and complex mobile edge network, heterogeneous devices with varying constraints are involved. This raises challenges of communication costs, resource allocation, and privacy and security in the implementation of FL at scale. In this survey, we begin with an introduction to the background and fundamentals of FL. Then, we highlight the aforementioned challenges of FL implementation and review existing solutions. Furthermore, we present the applications of FL for mobile edge network optimization. Finally, we discuss the important challenges and future research directions in FL.

In pharmaceutical sciences, a crucial step of the drug discovery process is the identification of drug-target interactions. However, only a small portion of the drug-target interactions have been experimentally validated, as the experimental validation is laborious and costly. To improve the drug discovery efficiency, there is a great need for the development of accurate computational approaches that can predict potential drug-target interactions to direct the experimental verification. In this paper, we propose a novel drug-target interaction prediction algorithm, namely neighborhood regularized logistic matrix factorization (NRLMF). Specifically, the proposed NRLMF method focuses on modeling the probability that a drug would interact with a target by logistic matrix factorization, where the properties of drugs and targets are represented by drug-specific and target-specific latent vectors, respectively. Moreover, NRLMF assigns higher importance levels to positive observations (i.e., the observed interacting drug-target pairs) than negative observations (i.e., the unknown pairs). Because the positive observations are already experimentally verified, they are usually more trustworthy. Furthermore, the local structure of the drug-target interaction data has also been exploited via neighborhood regularization to achieve better prediction accuracy. We conducted extensive experiments over four benchmark datasets, and NRLMF demonstrated its effectiveness compared with five state-of-the-art approaches.

Location-based social networks (LBSNs) offer researchers rich data to study people's online activities and mobility patterns. One important application of such studies is to provide personalized point-of-interest (POI) recommendations to enhance user experience in LBSNs. Previous solutions directly predict users' preference on locations but fail to provide insights about users' preference transitions among locations. In this work, we propose a novel categoryaware POI recommendation model, which exploits the transition patterns of users' preference over location categories to improve location recommendation accuracy. Our approach consists of two stages: (1) preference transition (over location categories) prediction, and (2) category-aware POI recommendation. Matrix factorization is employed to predict a user's preference transitions over categories and then her preference on locations in the corresponding categories. Real data based experiments demonstrate that our approach outperforms the state-of-the-art POI recommendation models by at least 39.75% in terms of recall.

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