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We presented two cases of COVID-19 associated SARS-CoV-2 infection during third trimester of pregnancy. Both mothers and newborns had excellent outcomes. We failed to identify SARS-CoV-2 in all the products of conception and the newborns. This report provided evidence of low risk of intrauterine infection by vertical transmission of SARS-CoV-2.

We present a way for symmetric multiparty-controlled teleportation of an arbitrary two-particle entangled state based on Bell-basis measurements by using two Greenberger-Horne-Zeilinger states, i.e., a sender transmits an arbitrary two-particle entangled state to a distant receiver, an arbitrary one of the n + 1 agents via the control of the others in a network. It will be shown that the outcomes in the cases that n is odd or it is even are different in principle as the receiver has to perform a controlled-not operation on his particles for reconstructing the original arbitrary entangled state in addition to some local unitary operations in the former. Also we discuss the applications of this controlled teleporation for quantum secret sharing of classical and quantum information. As all the instances can be used to carry useful information, its efficiency for qubits approaches the maximal value.Horne-Zeilinger (GHZ) state |ψ L = 1 √ 2 (|1010 + |0101 ). Recently, Rigolin [17] showed a way to teleport an arbitrary two-qubit entangled state with a four-particle entangled state |ψ R = 1 2 (|0000 + |0101 + |1010 + |1111 ) and four-particle joint measurements.Recently, controlled teleporation for a single-qubit |χ = a| ↑ + b| ↓ [33,34] [35] have been studied. In those teleportation protocols, the qubits can be regenerated by one of the receivers with the help of the others. Those principles can be used to split a quantum secret in QSS [19]. In this paper, we will present a symmetric protocol for multiparty-controlled teleportation of an arbitrary two-particle entangled state with two GHZ states and

A scheme for multiparty quantum state sharing of an arbitrary two-particle state is presented with Einstein-Podolsky-Rosen pairs. Any one of the N agents has the access to regenerate the original state with two local unitary operations if he collaborates with the other agents, say the controllers. Moreover, each of the controllers is required to take only a product measurement σx ⊗ σx on his two particles, which makes this scheme more convenient for the agents in the applications on a network than others. As all the quantum source can be used to carry the useful information, the intrinsic efficiency of qubits approaches the maximal value. With a new notation for the multipartite entanglement, the sender need only publish two bits of classical information for each measurement, which reduces the information exchanged largely.

We present a scheme for symmetric multiparty quantum state sharing of an arbitrary m-qubit state with m Greenberger-Horne-Zeilinger states following some ideas from the controlled teleportation [Phys. Rev. A 72, 02338 (2005)]. The sender Alice performs m Bell-state measurements on her 2m particles and the controllers need only to take some single-photon product measurements on their photons independently, not multipartite-entanglement measurements, which makes this scheme more convenient than the latter. Also it does not require the parties to perform a controlled-NOT gate on the photons for reconstructing the unknown m-qubit state and it is an optimal one as its efficiency for qubits approaches 100% in principle.

Two schemes for sharing an arbitrary two-qubit state based on entanglement swapping are proposed with Bell-state measurements and local unitary operations. One is based on the quantum channel with four Einstein-Podolsky-Rosen (EPR) pairs shared in advance. The other is based on a circular topological structure, i.e., each user shares an EPR pair with his neighboring one. The advantage of the former is that the construction of the quantum channel between the agents is controlled by the sender Alice, which will improve the security of the scheme. The circular scheme reduces the quantum resource largely when the number of the agents is large. Both of those schemes have the property of high efficiency as almost all the instances can be used to split the quantum information. They are more convenient in application than the other schemes existing as they require only two-qubit entanglements and two-qubit joint measurements for sharing an arbitrary two-qubit state.

Diosbulbin B (DIOB), a furan-containing diterpenoid lactone, is the most abundant component of Dioscorea bulbifera L. (DB), a traditional Chinese medicine herb. Administration of purified DIOB or DB extracts has been reported to cause liver injury in animals. The mechanisms of DIOB-induced hepatotoxicity remain unknown. The major objective of this study was to identify reactive metabolites of DIOB. A DIOB-derived cis-enedial was trapped by N-acetyl lysine (NAL) and glutathione (GSH) or N-acetyl cysteine (NAC) in rat and human liver microsomal incubation systems after exposure to DIOB. Four metabolites (M1-M4) associated with GSH were detected by liquid chromatography coupled to tandem mass spectrometry. Apparently, M1 was derived from both NAL and GSH. M2 and M3 resulted from the reaction of GSH without the involvement of NAL. Two molecules of GSH participated in the formation of M4. M2 and M3 were also detected in bile and urine of rats given DIOB. M5, a DIOB-derived NAC/NAL conjugate, was detected in microsomal incubations with DIOB fortified with NAC and NAL as trapping agents. Biomimetic M1-M5 were prepared by oxidation of DIOB with Oxone for metabolite identification. Microsomal incubation study demonstrated that ketoconazole inhibited the production of the enedial in a concentration-dependent manner, and CYP3A4 was found to be the enzyme responsible for the metabolic activation of DIOB. The metabolism study facilitates the understanding of the role of bioactivation of DIOB in its hepatotoxicity.

The success of future clinical trials with oncolytic viruses depends on the identification and the control of mechanisms that modulate their therapeutic efficacy. In particular, little is known about the role of autophagy in infection by attenuated measles virus of the Edmonston strain (MV-Edm). We investigated the interaction between autophagy, innate immune response, and oncolytic activity of MV-Edm, since the antiviral immune response is a known factor limiting virotherapies. We report that MV-Edm exploits selective autophagy to mitigate the innate immune response mediated by DDX58/RIG-I like receptors (RLRs) in nonsmall cell lung cancer (NSCLC) cells. Both RNA interference (RNAi) and overexpression approaches demonstrate that autophagy enhances viral replication and inhibits the production of type I interferons regulated by RLRs. We show that MV-Edm unexpectedly triggers SQSTM1/p62-mediated mitophagy, resulting in decreased mitochondrion-tethered mitochondrial antiviral signaling protein (MAVS) and subsequently weakening the innate immune response. These results unveil a novel infectious strategy based on the usurpation of mitophagy leading to mitigation of the innate immune response. This finding provides a rationale to modulate autophagy in oncolytic virotherapy. IMPORTANCE In vitro studies, preclinical experiments in vivo, and clinical trials with humans all indicate that oncolytic viruses hold promise for cancer therapy. Measles virus of the Edmonston strain (MV-Edm), which is an attenuated virus derived from the common wild-type measles virus, is paradigmatic for therapeutic oncolytic viruses. MV-Edm replicates preferentially in and kills