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A high temporal–spatial resolution (1 hr/1 km) gridded temperature data set with a long time‐series (2006–2015) is established for Zhejiang province, China, which has a complex terrain, including plains, hills, basins, mountains, islands and oceans. A comprehensive analysis method is used to combine regional surface station data with reanalysis data from the European Centre for Medium‐Range Weather Forecasts (ECMWF) such that the observations at the stations are reproduced, and the reanalysis data provide the spatial structure for the interpolation. The elevation correction method and inverse distance‐weighted interpolation method are selected for comparison. The quality of the data set is evaluated and analysed by comparison with the cross‐validation results, third‐party data validation and other gridded data sets. The results show that the comprehensive analysis method provides the best outcome, followed by the inverse distance‐weighted method, and the reanalysis data elevation correction method has the worst result. The temperature error obtained from the gridding methods increases with altitude, decreases with increasing station density and varies with different synoptic conditions. The obtained data set can describe the temperature feature of peaks and valleys more precisely, which produces lower errors and higher spatial correlation co‐efficients compared with observation than the other gridded data sets. Therefore, the established data set can meet the needs of fine meteorological businesses and has potential applications in many fields.

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Zearalenone (ZEA) exposure has carcinogenic effects on human and animal health by exhibiting intestinal, hepatic, and renal toxicity. At present, the un-derlying mechanisms on how ZEA induces apoptosis and damage to tissues still remain unclear. In this study, we aimed to identify genes that modulate the cellular response to ZEA using clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 screening, and further validate novel gene functions to elucidate molecular mechanisms underlying particular biological processes in vivo and in vitro. Two ZEA-resistant cell lines, designated Ov-KCNJ4 and Ov-KCNJ12, were yielded by CRISPR activation screening which had significant changes in ZEA resistance and growth rates. Results showed that ZEA could interact with the cell membrane proteins KCNJ4 and KCNJ12, inducing cell cycle arrest, disruption of DNA replication and base excision repair. Overexpression of KCNJ4 and KCNJ12 was involved in ZEA resistance by regulating cell cycle to neutralize toxicity, sustaining mitochondrial morphology and function via at-tenuating the damage from oxidative stress in the KCNJ4-mitoKATP pathway. In vivo experiments showed that AAV-KCNJ4 delivery significantly improved ZEA-induced renal impairment and increased antioxidative enzyme activity by im-proving mitochondrial function. Our findings suggest that increasing potassium channel levels may be a putative therapeutic target for mycotoxin-induced damage.