This article reports the first fluorescent microparticles (MPs, approximately 600 nm in diameter) constructed using helical substituted polyacetylene and prepared via a precipitation polymerization approach. The MPs judiciously combine this interesting helical conjugated acetylene, fluorescent material and polymeric particles in one entity. The monomer containing a dansyl group undergoes precipitation polymerization in butanone/n-heptane mixed solvent, with (nbd)Rh(+) B(-) (C6 H5 )4 as a catalyst. MPs with a regular morphology are formed in a high yield (>80 wt%). UV-vis spectroscopy demonstrates that the polymer chains making up the MPs adopt helical structures. The MPs show considerable fluorescence emission (λmax , 500 nm; excited at 340 nm). Based on SEM and fluorescence images, the formation mechanism of the MPs is proposed. This methodology opens up new ways to prepare functional microstructured materials derived from substituted polyacetylenes, and may also result in opportunities for new practical applications of polyacetylene and its derivatives.
A novel
chiral acetylenic monomer derived from cholic acid was
synthesized and structurally characterized. The monomer underwent
precipitation polymerization in tetrahydrofuran/n-heptane mixed solvent with [Rh(nbd)Cl]2 as catalyst.
Without adding porogen, porous microspheres were successfully prepared
in a high yield (>80 wt %). The formation mechanism of the porous
structure was proposed. Circular dichroism and UV–vis absorption
spectra demonstrated that the porous microspheres possessed optical
activity. The optical activity was originated in the chiral helical
conformations of substituted polyacetylene forming the microspheres.
The porous microspheres were further used as specific chiral additive
to induce enantioselective crystallization of racemic BOC-alanine,
in which BOC-l-alanine was preferentially induced forming
rod-like crystals with e.e. of 69%. This strongly indicates the significant
potential applications of the porous microspheres in chiral technologies.
The present study also provides a new approach to prepare chiral porous
polymer microspheres.
Breast cancer is the leading cause of cancer-related death in women around the world. It is urgently needed to identify genes associated with tumorigenesis and prognosis, as well as to elucidate the molecular mechanisms underlying the oncogenic process. Long noncoding RNAs (lncRNAs) are widely involved in the pathological and physiological processes of organisms and play an important role as oncogenes or tumor suppressor genes, affecting the development and progression of tumors. In this study, we focused on terminal differentiation-induced non-coding RNA (TINCR) (GeneID:257000) and explore its role in the pathogenesis of breast cancer. The results showed that TINCR was increased in breast cancer tissue, and high expression level of TINCR was associated with older age, larger tumor size, and advanced TNM stage. High level of TINCR can promote proliferation and metastasis of breast cancer cells, while downregulation of TINCR induces G1-G0 arrest and apoptosis. Mechanismly, TINCR can bind to staufen1 (STAU1) and then guide STAU1 (GeneID:6780) to bind to OAS1 mRNA (NM_016816.4) to mediate its stability. Thus low level of OAS1(GeneID:4938) can lead to cell proliferation and migration. This result elucidates a new mechanism for TINCR in breast cancer development and provides a survival indicator and potential therapeutic target for breast cancer patients.
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