A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used for quantification of 7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (NTTP) in the sitagliptin phosphate monohydrate active pharmaceutical ingredient. Chromatographic separation was achieved using a Agilent-ZORBAX SB-C18...
A facile synthesis of brivaracetam, a mainstream antiepileptic drug, is described employing direct de-esterification, enzymatic hydrolysis by porcine pancreatic lipase, and cyano hydrolysis-cyclization cascade as key steps. The concise process...
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