We conducted a multicentre cross-sectional survey of COVID-19 patients to evaluate the acute psychological impact on the patients with coronavirus disease 2019 (COVID-19) during isolation treatment based on online questionnaires from 2 February to 5 March 2020. A total of 460 COVID-19 patients from 13 medical centers in Hubei province were investigated for their mental health status using online questionnaires (including Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Patient Health Questionnaire-15, and Insomnia Severity Index scales). Among all 460 COVID-19 patients, 187 (40.65%) of them were healthcare workers (HCWs). 297 (64.57%) of them were females. The most common psychological problems were somatization symptoms (66.09%, n = 304), followed by depression (53.48%, n = 246), anxiety (46.30%, n = 213), problems of insomnia (42.01%, n = 171), and then self-mutilating or suicidal thoughts (23.26%, n = 107). Of all the patients, 15.65% (n = 72) had severe somatization symptoms, and 2.83% (n = 13) had severe (almost every day) self-mutilating or suicidal thoughts. The most common psychological problems for HCWs were somatization symptoms (67.84%, n = 125), followed by depression (51.87%, n = 97), anxiety (44.92%, n = 84), problems of insomnia (36.18%, n = 55), and then self-mutilating or suicidal thoughts (20.86%, n = 39). Patients with lower education levels were found to be associated with higher incidence of self-mutilating or suicidal thoughts (odds ratio [OR], 2.68, 95% confidence interval [95% CI], 1.66–4.33 [P < 0.001]). Patients with abnormal body temperature were found to be associated with higher incidence of self-mutilating or suicidal thoughts (OR, 3.97, 95% CI, 2.07–7.63 [P < 0.001]), somatic symptoms (OR, 2.06, 95% CI, 1.20–3.55 [P = 0.009]) and insomnia (OR, 1.66, 95% CI, 1.04–2.65 [P = 0.033]). Those with suspected infected family members displayed a higher prevalence of anxiety than those without infected family members (OR, 1.61, 95% CI, 1.1–2.37 [P = 0.015]). Patients at the age of 18–44 years old had fewer somatic symptoms than those aged over 45 years old (OR, 1.91, 95% CI, 1.3–2.81 [P = 0.001]). In conclusion, COVID-19 patients tended to have a high prevalence of adverse psychological events. Early identification and intervention should be conducted to avoid extreme events such as self-mutilating or suicidal impulsivity for COVID-19 patients, especially for those with low education levels and females who have undergone divorce or bereavement.
Osteosarcoma (OS) is a severe bone malignancy mainly occurring among adolescents under twenty-five years old. 1 It is generally characterized by bone pain and dysfunction. 2 Although various options for OS treatment, such as aggressive surgery and chemoradiotherapy, have improved the 5-year survival rate to approximately 60%, some OS patients still suffered from high rate of recurrence. 3 Therefore, comprehending the pathogenesis of OS is imperative to formulate efficacious therapeutic procedures.Long non-coding RNA (lncRNA) are 200 nt in length and can regulate post-transcription. 4 LncRNAs have been reported to have
Background N6-Methyladenosine (m6A) are significant in directing different genes’ expression and their phenotype in different types of cancers. On the other hand, the function of m6A in seminomatous germ cell tumors (SGCT) is still unexplored. Our research attempts to demonstrate the disease-free prognosis value of m6A RNA methylation regulators in SGCT. Methods The gene expression and accompanying clinical data of 65 SGCT tissues and 85 NSGCT tissues retrieved from the TCGA database were analyzed. A series of R packages were applied for our study. Results The landscape of m6A RNA methylation regulators in SGCT was displayed. All SGCT patients were grouped into two clusters by consensus clustering of m6A RNA methylation regulators, and the clusters were connected to the disease-free prognosis and clinicopathological characteristics of SGCT(p = 0.015). Furthermore, the risk score(1.52YTHDC1 + 2.22HNRNPC-2.735WTAP) model was obtained and constructed by the univariate Cox regression analysis, and the least absolute shrinkage and selection operator (LASSO) Cox regression. The risk score was interrelated with stage status and laterality status of SGCT. Under the same conditions, the right side may have a higher risk score than the left one. More significantly, the risk score can serve as an self-supporting disease-free prognostic marker for SGCT patients. Conclusions m6A RNA methylation regulators played an important role of SGCT in its disease-free survival prognosis.
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