Unconventional oil and gas operations using hydraulic fracturing can contaminate surface and groundwater with endocrine-disrupting chemicals. We have previously shown that 23 of 24 commonly used hydraulic fracturing chemicals can activate or inhibit the estrogen, androgen, glucocorticoid, progesterone, and/or thyroid receptors in a human endometrial cancer cell reporter gene assay and that mixtures can behave synergistically, additively, or antagonistically on these receptors. In the current study, pregnant female C57Bl/6 dams were exposed to a mixture of 23 commonly used unconventional oil and gas chemicals at approximately 3, 30, 300, and 3000 μg/kg·d, flutamide at 50 mg/kg·d, or a 0.2% ethanol control vehicle via their drinking water from gestational day 11 through birth. This prenatal exposure to oil and gas operation chemicals suppressed pituitary hormone concentrations across experimental groups (prolactin, LH, FSH, and others), increased body weights, altered uterine and ovary weights, increased heart weights and collagen deposition, disrupted folliculogenesis, and other adverse health effects. This work suggests potential adverse developmental and reproductive health outcomes in humans and animals exposed to these oil and gas operation chemicals, with adverse outcomes observed even in the lowest dose group tested, equivalent to concentrations reported in drinking water sources. These endpoints suggest potential impacts on fertility, as previously observed in the male siblings, which require careful assessment in future studies.
The physical characteristics are compared between shallow and deep water, in physics and acoustics, respectively. There is a specific sound speed profile in deep water, which is different from which in shallow water, resulting in different sound propagation law between them. In this paper, the sound field distributions are simulated under respective typical sound speed profile. The color figures of sound intensity are obtained, in which the horizontal ordinate is distance, and the vertical ordinate is depth. Then we can get some important characteristics of sound propagation. The results show that the seabed boundary is an important influence on sound propagation in shallow water, and sound propagation loss in deep water convergent zone is visibly less than which in spherical wave spreading. We can realize the remote probing using the acoustic phenomenon.
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