Label-free, real-time, and in-situ measurement on cell apoptosis is highly desirable in cell biology. We propose here a design of terahertz (THz) metamaterial-based biosensor for meeting this requirement. This metamaterial consists of a planar array of five concentric subwavelength gold ring resonators on a 10 μm-thick polyimide substrate, which can sense the change of dielectric environment above the metamaterial. We employ this sensor to an oral cancer cell (SCC4) with and without cisplatin, a chemotherapy drug for cancer treatment, and find a linear relation between cell apoptosis measured by Flow Cytometry and the relative change of resonant frequencies of the metamaterial measured by THz time-domain spectroscopy. This implies that we can determine the cell apoptosis in a label-free manner. We believe that this metamaterial-based biosensor can be developed into a cheap, label-free, real-time, and in-situ detection tool, which is of significant impact on the study of cell biology.
In order to obtain an atomic grating which can diffract light into the high-order directions more efficiently, a gain-phase grating (GPG) based on the spatial modulation of active Raman gain is theoretically presented. This grating is induced by a pump field and a standing wave in ultracold atoms, and it not only diffracts a weak probe field propagating along a direction normal to the standing wave into the high-order directions, but also amplifies the amplitude of the zero-order diffraction. In contrast with electromagnetically induced grating or electromagnetically induced phase grating, the GPG has larger diffraction efficiencies in the highorder directions. Hence it is more suitable to be utilized as an all-optical router in optical networking and communication.
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