Thymosin alpha 1 (Tα1), a 28-amino acid peptide, was first described and characterized from calf thymuses in 1977. This peptide can enhance T-cell, dendritic cell (DC) and antibody responses, modulate cytokines and chemokines production and block steroid-induced apoptosis of thymocytes. Due to its pleiotropic biological activities, Tα1 has gained increasing interest in recent years and has been used for the treatment of various diseases in clinic. Accordingly, there is an increasing need for the production of this peptide. So far, Tα1 used in clinic is synthesized using solid phase peptide synthesis. Here, we summarize the genetic engineering methods to produce Tα1 using prokaryotic or eukaryotic expression systems. The effectiveness of these biological products in increasing the secretion of cytokines and in promoting lymphocyte proliferation were investigated in vitro studies. This opens the possibility for biotechnological production of Tα1 for the research and clinical applications.
While extrusion molding with single-screw extruder, extrusion pressure comes into being from feeding section; it is one of the basic conditions to ensure that extrusion process can be carried on normally, in order to ensure molding process goes smoothly, it must meet the following requirement: extrusion pressure generated during the process must be sufficient. Therefore it has certain engineering significance to design structure of a single screw correctly that a mathematical model for formation of extrusion pressure during single-screw extrusion molding will have to be established. This paper conducted a research on theory of extrusion pressure when powder of pure UHMWPE resin is still in feeding section by molding in barrel of the single screw extruder specially designed for pure UHMWPE, and established a n-lamina model of powder materials or grain materials which is in feeding section and at the state of non-plug flow solid conveying, and it provided a method to calculate extrusion pressure of the n-lamina model, thus it enriched and perfected theory of single-screw extrusion molding.
This paper analyzed several important issues in theory of non-plug flow solid conveying, which is about the extrusion molding process of the single screw extruder, they are mainly: compressive stress on the front and rear ends of the surface, and ; an increase trend of compressive stress , ; pressure in feeding compression section of the screw, .
According to the theory of extrusion pressure by molding in barrel of the single screw extruder specially designed for pure UHMWPE, extrusion pressure generated during the process must be sufficient while extrusion molding with single-screw extruder. The mathematical model for formation of extrusion pressure in feeding section during single-screw extrusion molding has been established. This paper conducted a research on theory of extrusion pressure which is part of n-lamina model of non-plug flow solid conveying in feeding section by single-screw extrusion molding.
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