This study processed the recent in vivo survey results for over a thousand patients and optimized their neck and head CT angiography triggered timing (CTA-TT) via the inverse problem algorithm, which ensured the maximal ratio of both left and right arterial to upper sinuses (LRA/US). These results are instrumental in examining the ischemic stroke syndromes along the neck and head. These 1001 patients were randomly categorized into test surveyed (802 patients) and verification group (199 patients), then a six factors semi-empirical formula was constructed by the STATISTICA program. The six factors were assigned a patient’s biological data and preset of the CTA facility; namely Age, mean arterial pressure (MAP), heart rate (HR), contrast media dose (CMD), Pre (injected pressure of CMD), and body surface area (BSA). Each factor was normalized into dimensionless values and incorporated into the dataset matrix [Formula: see text] to analyze the coefficient matrix [Formula: see text]. The derived semi-empirical formula closely correlated with experimental data, according to the loss function [Formula: see text], correlation coefficient [Formula: see text], and variance of 0.8965. The formula verification for 199 more patients (verification group) yielded a correlation coefficient [Formula: see text]. Thus, it can be used for the CTA-TT estimation of patients without their preliminary tests, avoiding unnecessary irradiation. The estimated LRA/US was [Formula: see text] for the verification group in this study. A simplified three-factor formula, featuring only age, MAP, and BSA, was also proposed.
The TLD-100H readout system performance under various radioactive I-131 exposure doses was optimized by four key factors via the revised Taguchi dynamic quality loss function. Taguchi dynamic analysis and the orthogonal array reorganizing the essential factors are crucial for the optimization of the thermoluminescent dosimeter (TLD) readout system given strict criteria of multiple irradiated environments and long-term exposure for calibrated TLDs. Accordingly, 96 TLD-100H chips were selected and randomly categorized into three batches with eight groups (four TLD chips in each group). Four factors, namely (1) initial temperature, (2) heating rate, (3) maximal temperature, and (4) TLD preheat time before reading were organized into eight combinations according to Taguchi suggestion, whereas each factor was preset at two levels. All 96 [Formula: see text] chips were put in three concentric circles with 30, 60, and 90 cm radii for 48 h, surrounding the radioactive 150[Formula: see text]mCi ([Formula: see text][Formula: see text]MBq) I-131 capsule and exposed to the cumulative doses of 88.2, 18.6, and 8.6[Formula: see text]mSv for the respective radii, accordingly. The TLD readings obtained from each group were analyzed to derive the sensitivity, coincidence, and reproducibility, then those were reorganized to draw four fish-bone-plots for the optimization. The optimal option for the TLD readout system implied the combination of A1 (a [Formula: see text]C initial temperature), B1 (a [Formula: see text]C/s heating rate), C1 (a [Formula: see text]C maximal temperature), and D2 (a 15[Formula: see text]s preheat time), which was further verified by the follow-up measurements. The dominant factors were A (initial temperature) and B (heating rate), whereas C (maximal temperature) and D (preheat time) were minor and provided negligible contributions to the system performance optimization.
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