Background: Plasmodium falciparum-resistance to sulphadoxine-pyrimethamine (SP) has been largely reported among pregnant women. However, the profile of resistance markers to SP dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) in the general population are varied and not frequently monitored. Currently, SP is used as partner drug for artemisinin combination therapy (SP-artesunate) in some sub-Saharan African countries or as a prophylactic drug in intermittent preventive treatment of malaria during pregnancy and infants and in seasonal malaria chemoprevention (SMC). Profiling of P. falciparum-resistant genotypes to SP is dynamic and critical in providing data that would be useful for malaria control programmes. This study assessed the profile of dhfr and dhps genes genotypes among individuals with malaria in Lagos, Nigeria. Methods: Molecular markers of SP resistance were identified by nested PCR and sequenced among malaria positive dried blood spots (DBS) that were collected from individuals attending health facilities from

Lagos metropolis, the current economic capital of Nigeria is a low-lying coastal city endowed with a number of lagoons and wetland ecological assets. Lagos/Lekki Lagoons being the largest with a combined size of 646km2 are fringed on many sides by wetlands. Many of these wetlands have undergone severe spatial changes from rapid urbanization in the past three decades. The precise nature of these changes is largely unknown and unreported. As the area is experiencing intense development pressure, this study therefore examined the spatial changes in the wetlands fringing these lagoons using the integrated approach of remote sensing data and GIS with topographic maps providing baseline data. The objective is to quantify and establish the precise location and magnitude of these changes over the years from 1984 to 2006. Two types of wetlands are prevalent in the Lagos area namely: the swamps and mangroves. ENVI software was used along with parallelepiped supervised classification in processing the Landsat images. Results show that the mangrove wetlands decreased from 88.51km2 to 19.95km2 at -3.12km2 annually while swamps decreased from 344.75km2 to 165.37km2  at - 8.15km2 annually both between 1984 and 2006. Results further show that mangroves which were widespread in seven council areas around these lagoons in 1984, have dwindled to only four councils in 2006. These decreases are attributable to urban development pressures. Some of the implications of these losses and conservation issues are briefly highlighted.

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The Lagos Lagoon is under increased pressure from growth in human population, growing demands for natural resources, human activities, and socioeconomic factors. The degree of these activities and the impacts are directly proportional to urban expansion and growth. In the light of this situation, the objectives of this study were: (i) to estimate through satellite imagery analysis the extent of changes in the Lagos Lagoon environment for the periods 1984, 2002, 2013 and 2019 using Landsat-derived data on land cover, Land Surface Temperature (LST), Normalised Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI); and (ii) to evaluate the relationship between the derived data and determine their relative influence on the lagoon environment. The derived data were subjected to descriptive statistics, and relationships were explored using Pearson's correlation and regression analysis. The effect of land cover on LST was measured using the Contribution Index and a trend analysis was carried out. From the results, the mean LSTs for the four years were 22.68°C (1984), 24.34°C (2002), 26.46°C (2013) and 28.40°C (2019). Generally, the mean LSTs is in opposite trend with the mean NDVIs and EVIs as associated with their dominant land cover type. The strongest positive correlations were observed between NDVI and EVI while NDVI had the closest fit with LST in the regression. Built-up areas have the highest contributions to LST while vegetation had a cooling influence. The depletion in vegetative cover has compromised the biodiversity of this environment and efforts are required to reverse this trend.