Despite the substantial statistical and clinical heterogeneity, our findings indicate a probable association between PPI use and incident and recurrent CDI. This risk is further increased by concomitant use of antibiotics and PPI, whereas H2RAs may be less harmful.
In the bottom-most row (entitled " Community Patients " ) of Table 3, the estimated incidence should be 1.2 per 10,000 patient years rather than 1.2 per 1,000 patient years. Th e increase in CDI cases with PPI should be + 1 per 10,000 patients rather than + 1 per 1,000 patients. Th e NNT for harm should be 8,900 (6,400 -13,700) rather than 899 (638 -1,369).
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