Whether modern-style plate tectonics operated on early Earth is debated due to a paucity of definitive records of large-scale plate convergence, subduction, and collision in the Archean geological record. Archean Alpine-style sub-horizontal fold/thrust nappes in the Precambrian basement of China contain a Mariana-type subduction-initiation sequence of mid-ocean ridge basalt blocks in a 1600-kilometer-long mélange belt, overthrusting picritic-boninitic and island-arc tholeiite bearing nappes, in turn emplaced over a passive margin capping an ancient Archean continental fragment. Picrite-boninite and tholeiite units are 2698 ± 30 million years old marking the age of subduction initiation, with nappes emplaced over the passive margin at 2520 million years ago. Here, we show the life cycle of the subduction zone and ocean spanned circa 178 million years; conservative plate velocities of 2 centimeters per year yield a lateral transport distance of subducted oceanic crust of 3560 kilometers, providing direct positive evidence for horizontal plate tectonics in the Archean.

No abstract

The study demonstrated the feasibility of using transrenal DNA in mutation profiling for different stages of NSCLC patients. It highlights the importance of continual monitoring and has potential clinical utility in the clinical management of NSCLC.

Cefiderocol is a novel synthetic siderophore-conjugated antibiotic that hijacks the bacterial iron transport systems facilitating drug entry into cells, achieving high periplasmic concentrations. This systematic review analyzed the currently available literature on cefiderocol. It summarized in vitro susceptibility data, in vivo antimicrobial activity, pharmacokinetics/pharmacodynamics (PK/PD), clinical efficacy, safety and resistance mechanisms of cefiderocol. Cefiderocol has potent in vitro and in vivo activity against multidrug-resistant (MDR) Gram-negative bacteria, including carbapenem-resistant isolates. But New Delhi Metallo-β-lactamase (NDM)- positive isolates showed significantly higher MICs than other carbapenemase-producing Enterobacterales, with a susceptible rate of 83.4% for cefiderocol. Cefiderocol is well-tolerated, and the PK/PD target values can be achieved using a standard dose regimen or adjusted doses according to renal function. Clinical trials demonstrated that cefiderocol was non-inferiority to the comparator drugs in treating complicated urinary tract infection and nosocomial pneumonia. Case reports and series showed that cefiderocol was a promising therapeutic agent in carbapenem-resistant infections. However, resistant isolates and reduced susceptibility during treatment to cefiderocol have already been reported. In conclusion, cefiderocol is a promising powerful weapon for treating MDR recalcitrant infections.

Flash floods occur in mountainous catchments with short response times, which are among the most devastating natural hazards in China. This paper intends to forecast and provide warnings of flash floods timely and precisely using the flash flood warning system, which is established by a new distributed hydrological model (the China flash flood hydrological model, CNFF-HM). Two ungauged mountainous regions, Shunchang and Zherong, are chosen as the study areas. The CNFF-HM is calibrated in five well-monitored catchments. The parameters for the ungauged regions are estimated by regionalization. River water stage data and reservoir water stage data from Shunchang, and reservoir water stage data from Zherong are used to validate the model. The model performs well and the average Nash-Sutcliffe efficiency (NSE) is above 0.8 for the five catchments. The validation shows the difference in the timing of flood peaks using the two types of water stage data is less than 1 h. The rising and declining trends of the floods correspond to the observed trends over the entire validation process. Furthermore, the flash flood warning system was effectively applied in flash flood event on 28 September 2016 in Zherong. Thus, the CNFF-HM with regionalization is effective in forecasting flash floods for ungauged mountainous regions.