Background and purposeAcupuncture is widely used in clinical practice for the treatment of vascular diseases. However, the protocol, efficacy, and mechanism of acupuncture in animal models of vascular dementia are still controversial. Based on the above problems, we initiated this comprehensive study.MethodsTo analyze the literatures included in this study, 4 databases were searched and the SYRCLE's Risk of bias tool was employed. To perform the subgroup analysis of different acupuncture methods and the Review Manager 5.3 was applied. Meanwhile, the pairwise and network meta-analysis were conducted using Addis 1.16.8. The outcomes included escape latency, number of crossings, time spent in the target quadrant, and swimming speed.ResultsForty-two studies with a total of 1,486 animals were included in this meta-analysis. According to the results from subgroup analysis, GV20 + ST36 (Baihui + bilateral Zusanli) combined with 14-day manual acupuncture can obtain best improvement of the rats cognitive function among all acupuncture regimens (MD: −23.41; 95%CI: −26.66, −20.15; I2 = 0%; P < 0.001). The heterogeneity of other acupuncture treatments was significantly higher than that of GV20 + ST36, because the treatment courses were not uniform. Pair-wise and network comparisons are highly consistent. The major results of the network meta-analysis were as follows, In comparison to the impaired group, the acupuncture group showed significantly reduced escape latency (MD: −25.87; 95%CI: −30.75, −21.12), increased number of original platform crossings (MD: 2.63; 95%CI: 1.94, 3.34) and time spent in the target quadrant (MD: 7.88; 95%CI: 4.25, 11.44). The overall results of the network meta-analysis are as follows: the normal and sham-operated groups performed the best, followed by medicine and acupuncture, while no effect was found in the impaired group treated with non-acupoint and palliative.ConclusionsAcupuncture significantly improves cognitive function in rats with vascular dementia. Compared to other acupuncture plans, (GV20 + ST36, MA) and 14 -day manual acupuncture can be used to obtain better results. The main mechanism of acupuncture in the treatment of vascular dementia is reduced oxidative stress, neuronal inflammation, and apoptosis, as well as the increased synaptic plasticity and neurotransmitters.Systematic review registrationhttps://inplasy.com/inplasy-2021-11-0036/, identifier: INPLASY2021110036.
Review question / Objective: Is acupuncture effective in animal models of Alzheimer 's disease? P: animal. I: Acupuncture, drug, sham operation, sham acupuncture. C: normal group or model group. O: morriswater maze, Aβ and P-Tau content. S: RCT. Condition being studied: AD is the largest type of dementia worldwide, and cognitive decline is one of its main manifestations, however the pathogenic mechanisms of AD have not been fully elucidated. Animal studies are an important part of clinical research, and this study is mainly to investigate the efficacy of acupuncture in AD animal models. This team is composed of master 's degree, doctor' s degree and professor 's team and has academic conditions to carry out this study. INPLASY registration number: This protocol was registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 10 November 2022 and was last updated on 10 November 2022 (registration number INPLASY2022110048).
Review question / Objective: The aim of this review is to assess the efficacy and safety of acupuncture combined with traditional Chinese medicine for dry eye. Condition being studied: Relying on the research background of Guangzhou University of Chinese Medicine.we formed a research team with master's degree and doctor's degree to study evidence-based medicine. According to the hot spots of scientific research, the literature on acupuncture and moxibustion in the treatment of dry eye were retrieved and screened, and the included literature was evaluated, and the data were extracted. The extracted data were analyzed and reliable conclusions were drawn. INPLASY registration number: This protocol was registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 11 February 2022 and was last updated on 11 February 2022 (registration number INPLASY202220033).
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