Objectives
The aim of this study was to compare the value of the AI‐SONIC ultrasound‐assisted diagnosis system versus contrast‐enhanced ultrasound (CEUS) for differential diagnosis of thyroid nodules in diffuse and non‐diffuse backgrounds.
Methods
A total of 555 thyroid nodules with pathologically confirmed diagnosis were included in this retrospective study. The diagnostic efficacies of AI‐SONIC and CEUS for differentiating benign from malignant nodules in diffuse and non‐diffuse backgrounds were evaluated, with pathological diagnosis as the gold standard.
Results
The agreement between AI‐SONIC diagnosis and pathological diagnosis was moderate in diffuse backgrounds (κ = 0.417) and almost perfect in non‐diffuse backgrounds (κ = 0.81). The agreement between CEUS diagnosis and pathological diagnosis was substantial in diffuse backgrounds (κ = 0.684) and moderate in non‐diffuse backgrounds (κ = 0.407). In diffuse backgrounds, AI‐SONIC had slightly higher sensitivity (95.7 vs 89.4%, P = .375), but CEUS had significantly higher specificity (80.0 vs 40.0%, P = .008). In non‐diffuse background, AI‐SONIC had significantly higher sensitivity (96.2 vs 73.4%, P < .001), specificity (82.9 vs 71.2%, P = .007), and negative predictive value (90.3 vs 53.3%, P < .001).
Conclusion
In non‐diffuse backgrounds, AI‐SONIC is superior to CEUS for differentiating malignant from benign thyroid nodules. In diffuse backgrounds, AI‐SONIC could be useful for screening of cases to detect suspicious nodules requiring further examination by CEUS.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.