Background/Aims
Although disturbed sleep is associated with cognitive deficits, the association
between sleep disturbance and Alzheimer’s disease (AD) pathology is unclear. In
this pilot study, we examined the extent to which sleep duration, sleep quality, and
sleep-disordered breathing (SDB) are associated with β-amyloid (Aβ)
deposition in the brains of living humans.
Methods
We studied 13 older adults (8 with normal cognition and 5 with mild cognitive
impairment (MCI)). Participants completed neuropsychological testing, polysomnography
and Aβ imaging with [11C]-Pittsburgh compound B.
Results
Among participants with MCI, higher apnea-hypopnea index and oxygen
desaturation index were associated with greater Aβ deposition, globally and
regionally in the precuneus. There were no significant associations between SDB and
Aβ deposition among cognitively normal participants. There were no significant
associations between sleep duration or sleep fragmentation and Aβ
deposition.
Conclusion
These preliminary results suggest that, among older adults with MCI, greater
SDB severity is associated with greater Aβ deposition.
Objectives: In 2014, the National Board of Public Health Examiners performed a job task analysis (JTA) to revise the Certified in Public Health (CPH) examination. The objectives of this study were to describe the development, administration, and results of the JTA survey; to present an analysis of the survey results; and to review the implications of this first-ever public health JTA.
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