Early reports suggested that solid organ transplant (SOT) recipients maybe at higher risk of hospitalization, intensive care unit (ICU) stays, and death when compared to general population. 1 Of 59 adult SOT patients diagnosed with Coronavirus Disease 2019 at Westchester Medical Center from March-August 2020, 63% required hospitalization, 19% required ICU stay, 14% required mechanical ventilation, and 12% died. In a prior study of 482 SOT recipients with COVID-19 from more than 50 centers, a significant number of patients required hospitalization (78%), mechanical ventilation (31%) and 20.5% patients died during 28-day follow-up. 2 LETTER TO THE EDITOR received treatment with Bamlanivimab in the non-hospitalized setting. (Table 1). The patients were male-predominant (80%), had mean age of 53 (39-66) years, had mean body mass index of 28.4 (20-35), and were on average 43 (10-79) months post-transplantation.Patients received infusion on average of 3.3 (1-10) days after the onset of the symptoms. Other interventions included lowering/stopping mycophenolate (40%) and lowering the dose of calcineurin inhibitor (70%). Besides underlying immunosuppression, the patients had multiple other risk factors for progression of disease including age >65 years (10%), diabetes (30%), chronic cardiac disease (40%), and chronic kidney disease (20%). Adverse events were rare with only one of 10 patients developing mild pruritus during infusion.Patients were followed for a mean of 22 (14-27) days with none experiencing progression of COVID-19 symptoms or requiring hospitalization. When compared to our center's earlier experience, the access to diagnostic tests and notification process was streamlined during the study period. This allowed us an opportunity to intervene and to offer treatment with monoclonal antibody to our SOT patients very early in the disease process.In this study, following the administration of Bamlanivimab to solid organ transplant patients diagnosed with mild-moderate COVID-19 in a non-hospitalized setting, no patient experienced symptom worsening or required hospitalization.
Background Many internal medicine (IM) programs have reorganized their resident continuity clinics to improve trainees' ambulatory experience. Downstream effects on continuity of care and other clinical and educational metrics are unclear.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.