In a research program, co-sponsored by Bechtel Power Corporation and CounterQuake Corporation, the seismic performance of steel plate added damping and stiffness (ADAS) elements was investigated through a series of sub-assemblage experiments and by the earthquake simulator testing of a three story ductile moment resisting space frame (DMRSF) upgraded with ADAS elements. The sub-assemblage testing of the ADAS elements demonstrated their stable hysteresis for a large number of yielding cycles. The addition of the ADAS system (ADAS elements and chevron braces) to the DMRSF limited the frame's response to acceptable levels during severe earthquake simulation. The research program clearly demonstrated that ADAS elements can be used to effectively upgrade moment resisting frames (MRFs) and concentrically braced frames (CBFs) to achieve a moderately stiff building with extremely good energy dissipation characteristics. The implications of the research results for the design and upgrade of buildings using ADAS elements, and potential uses for ADAS elements, are presented in the latter part of the paper.

Affinity-purified antibodies raised against the peptide sequence H3 (349-358) receptor specifically recognized two protein species with Mr 62,000 and 93,000 in adult mouse forebrain membranes. Both immunoreactive species were suppressed greatly by preincubation of the antibody with the respective peptide. Immunohistochemical analysis using affinity-purified anti-H3 (349-358) antibodies yielded a high degree of coincidence with ligand-autoradiographical information, with high levels detected in the CA3 and dentate gyrus of the hippocampus, laminae V of the cerebral cortex, the olfactory tubercle, Purkinje cell layer of the cerebellum, substantia nigra, globus pallidus, thalamus and striatum. This study suggests further biochemical evidence for multiple H3 receptor subtypes and the widespread distribution of the H3 receptor in the mammalian brain.

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