Twenty‐six cases of osteogenic sarcoma of the somatic soft tissue were found during a review of more than 2,100 somatic soft‐tissue sarcomas in the files of the Mayo Clinic. These cases bring the total reported in the English literature through 1968 to 94. In the present series, no tumors occurred during the first two decades of life, in contrast to those primary in bone in which the peak incidence is in the second decade. Twenty‐four tumors were found in the limbs and limb girdles, and two in the retroperitoneum. The spectrum of histologic patterns as described for osteogenic sarcoma in bone was applied to establish the diagnosis. Five tumors were subtyped as chondroblastic, 10 as fibroblastic, and 11 as osteoblastic; all were poorly differentiated. Sarcomas with benign osseous or chondromatous metaplasia, mixed mesenchymal sarcomas, pseudo‐malignant tumors of soft parts (niyositis ossificans), and parosteal osteogenic sarcomas were excluded. In the series, 21 patients had died. Of the 5 living patients, only 2 are long‐term survivors (8 and 12 years). The average survival period was between 3 and 4 years, although 3 patients died with recurrent or mctastatic disease 7, 9, and 14 years after initial treatment. No histologic difference could be detected between tumors with a rapid clinical course and those with a prolonged course.
A series of N-heterocyclic carbene (NHC) complexes of Ge(II) were synthesized and structurally characterized. Unlike previous observations, the carbenic carbon-germanium bond length does not vary systematically with the electronic demands of the substituents on the germanium center. Computational analysis of the energetic and structural metrics of model compounds is consistent with a lack of a substituent effect on the carbenic carbon-germanium bond length.
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