No abstract

An enantiopure β-lactam with a suitably disposed electron withdrawing group on nitrogen, participated in a π-allylpalladium mediated reaction with 2,6-dichloropurine tetrabutylammonium salt to afford an advanced cis-1,4-substituted cyclopentenoid with both high regio- and stereoselectivity. This advanced intermediate was successfully manipulated to the total synthesis of (-)-Abacavir.

The synthesis, solution complexation behaviour and solvent extraction ability of related chelating mono-and bis-(benzimidazole)phosphinate ligands 8 and 9 has been assessed. 31P NMR, Ñuorescence and absorption spectroscopy and electrospray mass spectrometry revealed preferential formation of 1 : 1 complexes with the divalent ions Zn, Co and Ni, and complex formation with the bidentate ligand. Extraction studies showed ML 2 that 9 extracted with no extraction of copper(II), but avid extraction of copper(I), generated in situ, Zn [ Co A Ni consistent with the ligandÏs preference for the binding of tetrahedrally-coordinating metal ions.

No abstract

The cyclo cocondensation of triethylenetetramine with arylpyruvaldehydes is templated by iron(m) chloride, to give a [ 12]aneN4 type diimine complex intermediate which may be reduced and demetallated in situ with sodium borohydride giving the saturated [ 12]aneN4 metal-free macrocycle in up to 60% overall yields; photophysical studies are used to demonstrate the similarity between the aryl functionalised [ 12]aneN4 derivatives formed by this route and analogues derived from [12]aneN4 itself.