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Background and Purpose— Endovascular treatment for large vessel occlusion in ischemic stroke has proven to be effective in large clinical trials. We aimed to provide real-world estimates of endovascular treatment reperfusion rates and functional outcome on a countrywide scale. Methods— Two thousand seven hundred ninety-four patients with large vessel occlusion were included into an investigator-initiated, industry-independent, prospective registry in 25 sites in Germany between June 2015 and April 2018. The primary outcome was the score on the modified Rankin Scale ranging from zero (no symptoms) to 6 (death) at 3 months. Secondary analyses included the prediction of a good outcome (modified Rankin Scale, 0–2). Dichotomized analyses of predictors were performed using logistic regression adjusted for potential confounders. Results— Median age was 75 years (interquartile range, 64–82); median National Institutes of Health Stroke Scale score was 15 (interquartile range, 10–19). Vessel occlusion was in the anterior circulation in 2265 patients (88%) and in the posterior circulation in 303 patients (12%). Intravenous alteplase before endovascular treatment was given in 1457 patients (56%). Successful reperfusion was achieved in 2143 subjects (83%). At 3 months, 854 patients (37%) showed a good outcome; mortality was 29%. There was no difference between anterior and posterior circulation occlusions ( P =0.27). Significant predictors for a good outcome were younger age (odds ratio [OR], 1.06; 95% CI, 1.05–1.07), no interhospital transfer (OR, 1.39; 95% CI, 1.03–1.88), lower stroke severity (OR, 1.10; 95% CI, 1.08–1.13), smaller infarct size (OR, 1.26; 95% CI, 1.15–1.39), alteplase use (OR, 1.49; 95% CI, 1.08–2.06), and reperfusion success (OR, 1.69; 95% CI, 1.45–1.96). Conclusions— High rates of favorable outcome can be achieved on a countrywide scale by endovascular treatment. Mortality appears to be greater in the daily routine than otherwise reported by authors of large randomized trials. There were no outcome differences between the anterior and posterior circulation. Clinical Trial Registration— URL: https://www.clinicaltrials.gov . Unique identifier: NCT03356392.

After introduction of posaconazole prophylaxis for patients with AML, the number of febrile days, the incidence rate of IFDs and aspergillosis and the duration of hospitalization decreased significantly.

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The CD30-targeting Ab-drug conjugate brentuximab vedotin (SGN-35) was recently approved for the treatment of relapsed Hodgkin lymphoma and anaplastic large-cell lymphoma by the Food and Drug Administration. In the present study, we report the experience of the German Hodgkin Study Group with brentuximab vedotin as single agent in 45 patients with refractory or relapsed CD30 ؉ Hodgkin lymphoma who were treated either in a named patient program (n ‫؍‬ 34) or in the context of a safety study associated with the registration program of this drug. In these very heavily pretreated patients, an objective response rate of 60%, including 22% complete remissions, could be documented. The median duration of response was 8 months. This retrospective analysis supports the previously reported excellent therapeutic efficacy of brentuximab vedotin in heavily pretreated CD30 ؉ malignancies. This trial was registered at www.clinicaltrials.gov with identifier NCT01026233. (Blood. 2012;120(7): 1470-1472) IntroductionThe majority of Hodgkin lymphoma (HL) patients achieve longterm remission when treated with chemo-and radiotherapy. However, depending on initial risk factors and treatment, 10%-30% of patients progress or relapse. Up to 50% of these patients can still be cured with high-dose chemotherapy and autologous stem cell transplantation (ASCT). 1,2 Patients with primary progressive HL or relapse within 12 months after initial therapy have a significantly poorer outcome than those with late relapse. 3,4 Although salvage therapy including high-dose chemotherapy and ASCT cures up to 50% of patients, the median overall survival (OS) after ASCT failure is only approximately 2 years (Sally Arai, Michelle Fanale, Sven deVos, A.E., Tim Illidge, P.B., Anan Younes, Franck Morschhauser, Sandra J. Horning, manuscript submitted, June 2012). 5,6 To improve the outcome of patients with relapsed or refractory disease and to reduce chemotherapy-associated side effects, several targeted drugs have been developed and are currently undergoing clinical evaluation in HL patients. The most advanced and promising new drug is the Ab-drug conjugate brentuximab vedotin (SGN-35). 6 Brentuximab vedotin consists of the chimeric anti-CD30 mAb cAC10 conjugated to 4 molecules of monomethyl auristatin E, a synthetic antitubulin chemotherapeutic agent. 7 In a phase 1 trial including 45 patients with relapsed or refractory CD30 ϩ hematologic malignancies, an overall response rate (ORR) of 67% in patients who received the maximum tolerated dose of 1.8 mg/kg could be documented. 8 For relapsed HL, these promising results were confirmed in a single-arm phase 2 trial including 102 heavily pretreated HL patients. 9 The ORR was 73% with a median duration of 6.7 months, including 32% complete remissions (CRs) with a median duration of 20.5 months and 40% partial remissions (PRs) with a median duration of 3.5 months. In anaplastic large cell lymphoma, a phase 2 trial with 58 patients led to an ORR of 86% with a median duration of 12.6 months. 10 In August 2011, the Food ...