The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described. The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number of potent compounds lacking sedation, ataxia, or lethality. 5-(2-Biphenylyl)-2-(1-methylhydrazino)-1,3,4-thiadiazole (4m) represents a new class of anticonvulsant agent and compares favorably with the standard drugs phenytoin, phenobarbital, and carbamazepine.
Reputation and brand management are topical issues in UK higher education but previous research has often focused on marketing practitioners within higher education (HE) institutions rather than the senior, strategic leaders. This paper, however, examines university Chief Executives' understanding, attitudes and interpretation of reputation and brand management.Current literature on defining reputation and brand, research on branding in higher education, and the role of leaders in brand management, are examined to give context to the work. Research was conducted through interviews with Vice-Chancellors, Principals and Rectors from a selection of fourteen universities representing three different 'generations' (the 1992 universities, those formed in the mid-20 th century, and older institutions) Whilst the work is exploratory in nature it does highlight this as a rapidly evolving area of perceived importance and discusses conclusions on some of the external and internal issues related to reputation and brand management in this sector.
Two different structural types of 2-aryl-1,3,4-thiadiazole amidines were synthesized and evaluated for anticonvulsant activity. Enhancement of the inherent anticonvulsant activity therein and separation of this activity from the accompanying sedative action of these compounds were attempted. The most potent compounds occurred in the 2-(trifluoromethyl)phenyl series of type 3 amidines, but they also possessed a relatively high level of neurotoxicity and sedation as demonstrated in the rotorod test.
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