Up to 1 June 2022, almost 12 billion vaccine doses for coronavirus disease 2019 (COVID-19) were administered worldwide. 1 People with diabetes were more probable to be hospitalized for COVID-19 and were observed to have in-hospital mortality as high as 25%. 2,3 Hence COVID-19 vaccination is not only recommended with priority in people with diabetes, it has also been shown to be effective in people with diabetes. 4,5 Our research group previously showed that humoral immune response 2-3 weeks after the second COVID-19 vaccination is similar in people with type 1 diabetes, type 2 diabetes and healthy controls, 6
Aims: To conduct a pooled analysis to assess the performance of intermittently scanned continuous glucose monitoring (isCGM) in association with the rate of change in sensor glucose in a cohort of children, adolescents, and adults with type 1 diabetes.
Material and Methods:In this pooled analysis, isCGM system accuracy was assessed depending on the rate of change in sensor glucose. Clinical studies that have been investigating isCGM accuracy against blood glucose, accompanied with collection time points were included in this analysis. isCGM performance was assessed by means of median absolute relative difference (MedARD), Parkes error grid (PEG) and Bland-Altman plot analyses.Results: Twelve studies comprising 311 participants were included, with a total of 15 837 paired measurements. The overall MedARD (interquartile range) was 12.7% (5.9-23.5) and MedARD differed significantly based on the rate of change in glucose (P < 0.001). An absolute difference of À22 mg/dL (À1.2 mmol/L) (95% limits of agreement [LoA] 60 mg/dL (3.3 mmol/L), À103 mg/dL (À5.7 mmol/L)) was found when glucose was rapidly increasing (isCGM glucose minus reference blood glucose), while a À32 mg/dL (1.8 mmol/L) (95% LoA 116 mg/dL (6.4 mmol/L), À51 mg/dL (À2.8 mmol/ L)) absolute difference was observed in periods of rapidly decreasing glucose.
Conclusions:The performance of isCGM was good when compared to reference blood glucose measurements. The rate of change in glucose for both increasing and Othmar Moser and Christoph Sternad share the first authorship.
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