This is the first reported case of an acquired FXIII inhibitor associated with mantle cell lymphoma in which the epitope specificity of the pathologic autoantibody was accurately defined. Antifibrinolytic therapy played a prominent role in the prevention of bleeding complications in the window period between initiation of immunosuppression and disappearance of the pathologic anti-FXIII autoantibody.
the PEG-AHG method. Antibody identification of the samples showed positive for IgG antibodies, which consist with daratumumab agent (IgG1κ). These results showed promising effect of MP method for pretransfusion test in patient with daratumumab.The main shortcoming of the MP test is its lack of adequate sensitivity in the Kell system. 3 However, this could be overcome by performing a supplementary antiglobulin reaction on the sensitized, polybrene-treated RBCs, 3 although there are still some limitations of the MP method, such as the need for further training laboratory technicians and inadequate sensitivity for Kell blood-type detection in some areas. With no interference with daratumumab, the MP method reveals its advantage in pretransfusion test in the era of targeted monoclonal therapy.
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