In this review, we provide an overview of conjugated organic semiconductors and their applications in biological sensing with a primary focus on the role of the organic semiconductor.
Small-molecule
organic semiconductors have displayed remarkable
electronic properties with a multitude of π-conjugated structures
developed and fine-tuned over recent years to afford highly efficient
hole- and electron-transporting materials. Already making a significant
impact on organic electronic applications including organic field-effect
transistors and solar cells, this class of materials is also now naturally
being considered for the emerging field of organic bioelectronics.
In efforts aimed at identifying and developing (semi)conducting materials
for bioelectronic applications, particular attention has been placed
on materials displaying mixed ionic and electronic conduction to interface
efficiently with the inherently ionic biological world. Such mixed
conductors are conveniently evaluated using an organic electrochemical
transistor, which further presents itself as an ideal bioelectronic
device for transducing biological signals into electrical signals.
Here, we review recent literature relevant for the design of small-molecule
mixed ionic and electronic conductors. We assess important classes
of p- and n-type small-molecule semiconductors, consider structural
modifications relevant for mixed conduction and for specific interactions
with ionic species, and discuss the outlook of small-molecule semiconductors
in the context of organic bioelectronics.
Poly(3,4-ethylenedioxythiophene) (PEDOT) is a well-known semiconducting polymer with favorable properties which find it often applied as the active material in biological sensors and electrochromic devices. However, PEDOT has several drawbacks which can prohibit its effective or long-term use, including weak adhesion to substrates such as ITO-coated glass, poorly controlled surface morphology, and reduced electrochemical stability over time. While a diverse range of approaches have been explored to overcome these issues, most involve additives or substrate modification, while solutions based on direct covalent adaptation are relatively lacking. We present a novel polymer based on covalently modified EDOT (PEDOT-Crown), featuring polar motifs and a 15-crown-5 moiety. Compared to PEDOT, PEDOT-Crown demonstrates a wealth of advantageous properties including: superior adhesion to ITO under physical and electrochemical duress; a more uniform surface morphology; and electrochemical properties including a higher contrast ratio, red-shifted polaron and bipolaron absorption features, bleaching of the neutral absorption band across a narrower voltage range, and more Faradaic rather than capacitive behavior. Additionally, we note that in the presence of Na + , PEDOT-Crown appears to show modified behavior in long-term electrochemical experiments. These features make PEDOT-Crown a material with improved suitability for application in biological sensing and electrochromic devices, compared to PEDOT.
A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.
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